NCOR2 抗体 (AA 2004-2310)
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Quick Overview for NCOR2 抗体 (AA 2004-2310) (ABIN2668570)
抗原
See all NCOR2 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 2004-2310
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原理
- SMRT / NCoR2 antibody (mAb) (Clone 5.10)
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纯化方法
- Protein G Chromatography
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免疫原
- This SMRT / NCoR2 antibody was raised against a recombinant protein corresponding to amino acids 2004-2310 of human SMRT / NCoR2.
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亚型
- IgG1
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anti-Nuclear Receptor Co-Repressor 2 (NCOR2) (AA 670-900) antibody
NCOR2 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Nuclear Receptor Co-Repressor 2 (NCOR2) (AA 2201-2525) antibodyNCOR2 适用: 人 ELISA, IF (cc), IF (p), IHC (p), IHC (fro), ICC 宿主: 兔 Polyclonal unconjugated
anti-Nuclear Receptor Co-Repressor 2 (NCOR2) (AA 1-110) antibodyNCOR2 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Nuclear Receptor Co-Repressor 2 (NCOR2) (AA 511-560) antibodyNCOR2 适用: 人, 小鼠, 大鼠, Pig, 斑马鱼 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Nuclear Receptor Co-Repressor 2 (NCOR2) (N-Term) antibodyNCOR2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Nuclear Receptor Co-Repressor 2 (NCOR2) (AA 541-590) antibodyNCOR2 适用: 人, 小鼠, 大鼠, Pig, Cow WB 宿主: 兔 Polyclonal unconjugated
anti-Nuclear Receptor Co-Repressor 2 (NCOR2) (C-Term) antibodyNCOR2 适用: 人, 小鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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浓度
- 1 μg/μL
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缓冲液
- Purified IgG in 70 mM Tris ( pH 8), 105 mM NaCl, 31 mM glycine, 0.07 mM EDTA, 30 % glycerol and 0.035 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions,Keep all reagents on ice when not in storage
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储存条件
- -20 °C
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储存方法
- Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.
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有效期
- 24 months
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: "Nuclear receptor corepressors partner with class II histone deacetylases in a Sin3-independent repression pathway." in: Genes & development, Vol. 14, Issue 1, pp. 45-54, (2000) (PubMed).
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- NCOR2 (Nuclear Receptor Co-Repressor 2 (NCOR2))
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别名
- SMRT / NCoR2
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背景
- SMRT / NCoR2 (Nuclear receptor corepressor 2, CTG repeat protein 26, SMAP270, Silencing mediator of retinoic acid and thyroid hormone receptor, Thyroid and retinoic-acid-receptor-associated corepressor, TRAC) is a transcriptional corepressor for nuclear receptors. SMRT / NCoR2 has been shown to play a role in regulating immune response, mediating DNA repair, and in neuronal differentiation and cardiac development. SMRT / NCoR2 is part of a large corepressor complex that contains SIN3A/B and histone deacetylases HDAC1 and HDAC2. It also includes TBL1, TBLR1, and GPS2 that help stabilize the overall structure of the complex. SMRT / NCoR2 mediates the transcriptional repression activity of nuclear receptors by promoting histone deacetylation and chromatin condensation, thus preventing access of the basal transcription machinery.
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分子量
- 300 kDa
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基因ID
- 9612
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NCBI登录号
- NP_006303
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途径
- Notch Signaling, Carbohydrate Homeostasis, Chromatin Binding, Regulation of Lipid Metabolism by PPARalpha
抗原
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