TWIST1 抗体
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北京 101111
Quick Overview for TWIST1 抗体 (ABIN2668516)
抗原
See all TWIST1 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- TWIST antibody (mAb)
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纯化方法
- Protein G Chromatography
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免疫原
- This TWIST antibody was raised against a recombinant protein corresponding to full-length mouse TWIST.
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亚型
- IgG1
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anti-Twist Homolog 1 (Drosophila) (TWIST1) (AA 100-202) antibody
TWIST1 适用: 人 WB, ELISA, IP, RNAi 宿主: 小鼠 Monoclonal 3E11 unconjugated
anti-Twist Homolog 1 (Drosophila) (TWIST1) (AA 9-74) antibodyTWIST1 适用: 人, 小鼠 WB, ELISA, IHC, ICC, FACS 宿主: 小鼠 Monoclonal 10E4E6 unconjugated
anti-Twist Homolog 1 (Drosophila) (TWIST1) (AA 9-74) antibodyTWIST1 适用: 人, 小鼠 WB, ELISA, IHC, FACS, IF/ICC 宿主: 小鼠 Monoclonal unconjugated
anti-Twist Homolog 1 (Drosophila) (TWIST1) (AA 100-202) antibodyTWIST1 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 2F8 unconjugated
anti-Twist Homolog 1 (Drosophila) (TWIST1) (AA 106-174) antibodyTWIST1 适用: 人 WB, ELISA, IP 宿主: 小鼠 Monoclonal 2G12 unconjugated
anti-Twist Homolog 1 (Drosophila) (TWIST1) (AA 1-100) antibodyTWIST1 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Twist Homolog 1 (Drosophila) (TWIST1) (AA 9-74) antibodyTWIST1 适用: 人 ELISA 宿主: 小鼠 Monoclonal 2F8E7 unconjugated
anti-Twist Homolog 1 (Drosophila) (TWIST1) (Center) antibodyTWIST1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Twist Homolog 1 (Drosophila) (TWIST1) antibodyTWIST1 适用: 人 WB, ICC, FACS, DB 宿主: 小鼠 Monoclonal Twist2C1a unconjugated
anti-Twist Homolog 1 (Drosophila) (TWIST1) (C-Term) antibodyTWIST1 适用: 人, 小鼠, 大鼠, 斑马鱼, Cow, 马, Pig, 犬, 豚鼠, 兔 WB, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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浓度
- 1 μg/μL
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缓冲液
- Purified IgG in 70 mM Tris ( pH 8), 105 mM NaCl, 31 mM glycine, 0.07 mM EDTA, 30 % glycerol and 0.035 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions,Keep all reagents on ice when not in storage
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储存条件
- -20 °C
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储存方法
- Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.
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有效期
- 24 months
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: "The histone methyltransferase MMSET/WHSC1 activates TWIST1 to promote an epithelial-mesenchymal transition and invasive properties of prostate cancer." in: Oncogene, Vol. 32, Issue 23, pp. 2882-90, (2013) (PubMed).
: "Snail2 is an essential mediator of Twist1-induced epithelial mesenchymal transition and metastasis." in: Cancer research, Vol. 71, Issue 1, pp. 245-54, (2011) (PubMed).
: "Twist1-induced invadopodia formation promotes tumor metastasis." in: Cancer cell, Vol. 19, Issue 3, pp. 372-86, (2011) (PubMed).
: "Twist relates to tubular epithelial-mesenchymal transition and interstitial fibrogenesis in the obstructed kidney." in: The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, Vol. 55, Issue 7, pp. 661-73, (2007) (PubMed).
: "Twist protein in mouse embryogenesis." in: Developmental biology, Vol. 189, Issue 2, pp. 205-14, (1997) (PubMed).
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- TWIST1 (Twist Homolog 1 (Drosophila) (TWIST1))
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别名
- TWIST
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背景
- TWIST is a regulator of transcription that serves as a master regulator of embryonic morphogenesis. Through its bHLH motif it interacts with many different transcription factors to affect multiple pathways of gene expression. TWIST plays a pivotal role in mesodermal, myoblast, and osteoblast differentiation. TWIST is involved in the epithelial-mesenchymal transition (EMT), a period during embryonic development characterized by loss of cell adhesion and increased cell mobility, essential events for mesoderm and neural tube formation. The EMT shares many features of metastatic cancer, and elevated levels of TWIST are observed in many types of cancer. Mutations in the gene encoding TWIST have been associated with Saethre-Chotzen syndrome, an inherited developmental disorder characterized by skull deformations, limb abnormalities, and facial dysmorphisim.
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分子量
- 21 kDa
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基因ID
- 7291
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NCBI登录号
- NP_000465
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途径
- p53 Pathway, Proton Transport, Tube Formation, Negative Regulation of Transporter Activity
抗原
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