DNMT1 抗体 (AA 637-651)
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北京 101111
Quick Overview for DNMT1 抗体 (AA 637-651) (ABIN2668504)
抗原
See all DNMT1 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 637-651
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原理
- DNMT1 antibody (mAb) (Clone 60B1220.1)
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纯化方法
- Protein G Chromatography
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免疫原
- This DNMT1 antibody was raised against a peptide corresponding to amino acid residues 637-651 of human DNMT1.
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亚型
- IgG
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anti-DNA (Cytosine-5)-Methyltransferase 1 (DNMT1) (AA 1-270) antibody
DNMT1 适用: 人 WB, IP, IF 宿主: 兔 Polyclonal unconjugated
anti-DNA (Cytosine-5)-Methyltransferase 1 (DNMT1) antibodyDNMT1 适用: 人, 小鼠, 大鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-DNA (Cytosine-5)-Methyltransferase 1 (DNMT1) antibodyKO Validated DNMT1 适用: 人 WB, IHC, IP, IF, ChIP 宿主: 兔 Monoclonal unconjugated
anti-DNA (Cytosine-5)-Methyltransferase 1 (DNMT1) antibodyKD Validated DNMT1 适用: 人 WB, FACS, IF (p) 宿主: 兔 Monoclonal 24GB5135 unconjugated Recombinant Antibody
anti-DNA (Cytosine-5)-Methyltransferase 1 (DNMT1) (AA 1448-1594) antibodyDNMT1 适用: 人, 猴 WB, IHC, ELISA 宿主: 小鼠 Monoclonal 7C11A2 unconjugated
anti-DNA (Cytosine-5)-Methyltransferase 1 (DNMT1) (AA 21-120) antibodyDNMT1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-DNA (Cytosine-5)-Methyltransferase 1 (DNMT1) (AA 1317-1616) antibodyDNMT1 适用: 人 IHC, ELISA 宿主: 小鼠 Monoclonal 2D10G8 unconjugated
anti-DNA (Cytosine-5)-Methyltransferase 1 (DNMT1) (AA 881-914) antibodyDNMT1 适用: 人, 小鼠 WB, IF, IHC (p) 宿主: 兔 Polyclonal RB51461 unconjugated
anti-DNA (Cytosine-5)-Methyltransferase 1 (DNMT1) (AA 1317-1616) antibodyDNMT1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1D5G2 unconjugated
anti-DNA (Cytosine-5)-Methyltransferase 1 (DNMT1) (AA 637-650) antibodyDNMT1 适用: 人 WB, IHC, IP, ChIP 宿主: 小鼠 Monoclonal 60B1220-1 unconjugated
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应用备注
- WB: 2 - 4 μg/mL dilution For DNMT1, we also offer AbFlex DNMT1 Recombinant Antibody (rAb). For details, see Catalog No. 91175.
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限制
- 仅限研究用
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浓度
- 0.5 μg/μL
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缓冲液
- PBS and 0.05 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions,Keep all reagents on ice when not in storage
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储存条件
- 4 °C,-20 °C
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储存方法
- Some products may be shipped at room temperature. This will not affect their stability or performance. Store at 4°C for short term. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.
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有效期
- 24 months
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: "Targeted disruption of DNMT1, DNMT3A and DNMT3B in human embryonic stem cells." in: Nature genetics, Vol. 47, Issue 5, pp. 469-78, (2015) (PubMed).
: "Analysis of the SWI/SNF chromatin-remodeling complex during early heart development and BAF250a repression cardiac gene transcription during P19 cell differentiation." in: Nucleic acids research, Vol. 42, Issue 5, pp. 2958-75, (2014) (PubMed).
: "Prenatal caloric restriction enhances DNA methylation and MeCP2 recruitment with reduced murine placental glucose transporter isoform 3 expression." in: The Journal of nutritional biochemistry, Vol. 25, Issue 2, pp. 259-66, (2014) (PubMed).
: "Chromium cross-links histone deacetylase 1-DNA methyltransferase 1 complexes to chromatin, inhibiting histone-remodeling marks critical for transcriptional activation." in: Molecular and cellular biology, Vol. 27, Issue 20, pp. 7089-101, (2007) (PubMed).
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- DNMT1 (DNA (Cytosine-5)-Methyltransferase 1 (DNMT1))
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别名
- DNMT1
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背景
- DNMT1 (DNA (cytosine-5)-methyltransferase) proteins are involved in DNA methylation in which a methyl group is added to a cytosine residue on DNA, commonly at the C5 position of a CpG dinucleotide. Three families of DNMTs have been identified: DNMT1, DNMT2, and DNMT3 (comprised of DNMT3A and DNMT3B). DNMT1 is the most abundant DNMT in somatic cells and shows a preference for methylating hemi-methylated DNA. It is considered to be a maintenance DNA methyltransferase that is important in the maintenance of specific patterns of methylation throughout cellular divisions. Methylation of mammalian DNA has long been recognized to play a major role in a number of cellular functions such as embryonic development, genetic imprinting, X chromosome inactivation and the control of gene expression. DNA methylation is generally associated with transcriptional repression.
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分子量
- 190 kDa
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基因ID
- 1786
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NCBI登录号
- NP_001370
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途径
- SARS-CoV-2 Protein Interactome, The Global Phosphorylation Landscape of SARS-CoV-2 Infection
抗原
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