PAX5 抗体 (Alexa Fluor 488)
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- 抗原 See all PAX5 抗体
- PAX5 (Paired Box 5 (PAX5))
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适用
- 人, 小鼠
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宿主
- 大鼠
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克隆类型
- 单克隆
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标记
- This PAX5 antibody is conjugated to Alexa Fluor 488
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应用范围
- Flow Cytometry (FACS)
- 纯化方法
- The antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 488 under optimal conditions.
- 克隆位点
- 1H9
- 亚型
- IgG2a kappa
- Top Product
- Discover our top product PAX5 Primary Antibody
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anti-Paired Box 5 (PAX5) (AA 192-301) antibody
PAX5 适用: 人 WB, ELISA, IHC (p), RNAi 宿主: 小鼠 Monoclonal 8F9 unconjugated
anti-Paired Box 5 (PAX5) (AA 235-382) antibodyPAX5 适用: 人 IHC, StM 宿主: 小鼠 Monoclonal PAX5-3735 unconjugated
anti-Paired Box 5 (PAX5) (AA 235-382) antibodyPAX5 适用: 人 WB, ELISA, IHC 宿主: 小鼠 Monoclonal 7D3 unconjugated
anti-Paired Box 5 (PAX5) (N-Term) antibodyVerified PAX5 适用: 人, 小鼠, 大鼠 WB, ELISA, IF 宿主: 山羊 Polyclonal unconjugated
anti-Paired Box 5 (PAX5) (AA 178-207) antibodyPAX5 适用: 人 WB, ELISA, IHC, FACS 宿主: 兔 Polyclonal unconjugated
anti-Paired Box 5 (PAX5) (AA 217-282) antibodyPAX5 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Paired Box 5 (PAX5) (AA 362-391) antibodyPAX5 适用: 人 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Paired Box 5 (PAX5) antibodyPAX5 适用: 人, 小鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Paired Box 5 (PAX5) antibodyPAX5 适用: 人 WB, ELISA, Coat 宿主: 小鼠 Monoclonal rPAX5-2060 unconjugated Recombinant Antibody
anti-Paired Box 5 (PAX5) (N-Term) antibodyPAX5 适用: 人, 小鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 限制
- 仅限研究用
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- 浓度
- 0.5 mg/mL
- 缓冲液
- Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Protect from prolonged exposure to light. Do not freeze.
- 储存条件
- 4 °C
- 储存方法
- The antibody solution should be stored undiluted between 2°C and 8°C
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- 抗原
- PAX5 (Paired Box 5 (PAX5))
- 别名
- Pax-5 (PAX5 产品)
- 别名
- PAX5 antibody, BSAP antibody, Pax-5 antibody, pax5-a antibody, RGD1565236 antibody, EBB-1 antibody, KLP antibody, Pax[Zf-b] antibody, noi antibody, pax2.1 antibody, pax2a antibody, paxzf-b antibody, paired box 5 antibody, paired box 5 L homeolog antibody, PAX5 antibody, pax5.L antibody, Pax5 antibody, pax5 antibody
- 背景
- Pax5, also known as BSAP (B cell specific activator protein), is a member of the paired box (Pax) family of transcription factors. PAX proteins are important regulators in early development, and alterations in the expression of their genes are thought to contribute to neoplastic transformation. Pax5 is the only member of the Pax family of transcription factors that is expressed in hematopoietic cells. During embryogenesis, Pax5 is transiently expressed in the brain of mice and in the mesencephalon and spinal cord of humans. Its expression is upregulated early in B cell development at the time of B cell commitment and is maintained throughout most subsequent stages. Suppression of Pax5 is essential for expression of Blimp-1 and the terminal differentiation of plasma cells. In the spleen, expression of Pax5 is higher in marginal zone B cells (B220+ CD21high CD23low) than in other B cells, especially the transition 1 stage (B220+ CD21- CD23-). In addition to its role in B cell development, Pax5 also affects VH-DJH heavy chain recombination as well as influencing the expression of many other B and non-B cell related proteins. Its expression has also been detected in developing CNS and testis and so the encoded protein may also play a role in neural development and spermatogenesis. This gene is located at 9p13, which is involved in t(9,14)(p13,q32) translocations recurring in small lymphocytic lymphomas of the plasmacytoid subtype, and in derived large-cell lymphomas. This translocation brings the potent E-mu enhancer of the IgH gene into close proximity of the PAX5 promoter, suggesting that the deregulation of transcription of this gene contributes to the pathogenesis of these lymphomas. Alternatively spliced transcript variants encoding different isoforms have been described but their biological validity has not been determined.
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