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IRF1 抗体

The 小鼠 单克隆 anti-IRF1 antibody is suitable to detect IRF1 in samples from 人. It has been validated for WB.
产品编号 ABIN2666257
发货至: 中国
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中国
北京 101111
No. 88 KeChuang 6th Street
Beijing Economic Technological Development Area
Room 801-803
4A Biotech Co.,Ltd.
Tel +86 (0512) 65829739 传真 +86 (010) 6788 5057

Quick Overview for IRF1 抗体 (ABIN2666257)

抗原

See all IRF1 抗体
IRF1 (Interferon Regulatory Factor 1 (IRF1))

适用

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宿主

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小鼠

克隆类型

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单克隆

标记

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This IRF1 antibody is un-conjugated

应用范围

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Western Blotting (WB)

克隆位点

13H3A44
  • 纯化方法

    Affinity purified.

    亚型

    IgG2a kappa
  • 应用备注

    Optimal working dilution should be determined by the investigator.

    限制

    仅限研究用
  • 浓度

    0.5 mg/mL

    缓冲液

    phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C

    储存方法

    Upon receipt, store undiluted at 4°C.
  • 抗原

    IRF1 (Interferon Regulatory Factor 1 (IRF1))

    别名

    IRF1

    背景

    IRF1 is the first identified member of the interferon regulatory transcription factor family. Its expression is induced in response to pathogen infection or the stimulation of several cytokines, including type I and II IFN, IL-1, IL-6, and TNF-α. Upon stimulation, IRF1 is transcriptionally activated by STAT1 and NFκB transcription factors via the GAS (interferon-gamma-activated sequence) element in the IRF1 promoter. IRF1 plays important roles in mediating immune response during infection and development of T cells and NK cells. In addition to the immunomodulatory functions, IRF1 has also shown to be involved in the regulation of cell cycle progression, tumor suppression, and apoptosis. IRF1-mediated transcription can be repressed by IRF2 through competing for the same binding region on the promoters.

    途径

    Interferon-gamma Pathway, Response to Growth Hormone Stimulus, Positive Regulation of Immune Effector Process, Hepatitis C, Autophagy
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