TICAM2 抗体
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北京 101111
Quick Overview for TICAM2 抗体 (ABIN2665412)
抗原
See all TICAM2 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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纯化方法
- The antibody was purified by affinity chromatography.
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亚型
- IgG2a kappa
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anti-Toll-Like Receptor Adaptor Molecule 2 (TICAM2) (C-Term) antibody
TICAM2 适用: 人, 小鼠, 大鼠 WB, ICC, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Toll-Like Receptor Adaptor Molecule 2 (TICAM2) (AA 1-235) antibodyTICAM2 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Toll-Like Receptor Adaptor Molecule 2 (TICAM2) (AA 1-235) antibodyTICAM2 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Toll-Like Receptor Adaptor Molecule 2 (TICAM2) (AA 150-200) antibodyTICAM2 适用: 人, 小鼠, 大鼠, 猴, Cow, Opossum WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Toll-Like Receptor Adaptor Molecule 2 (TICAM2) (C-Term) antibodyTICAM2 适用: 人, 小鼠, 大鼠 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
anti-Toll-Like Receptor Adaptor Molecule 2 (TICAM2) (AA 1-235) antibodyTICAM2 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Toll-Like Receptor Adaptor Molecule 2 (TICAM2) (AA 34-241) antibodyTICAM2 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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浓度
- 0.5 mg/mL
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缓冲液
- Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- The antibody solution should be stored undiluted between 2°C and 8°C.
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- TICAM2 (Toll-Like Receptor Adaptor Molecule 2 (TICAM2))
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别名
- TICAM-2
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背景
- TICAM-2, also known as TRIF-related adaptor molecule (TRAM), is a TIR domain containing protein that was found to act as an adaptor molecule during LPS-induced innate immune response. Upon infection by Gram-negative bacteria, TLR4 specifically recognizes LPS and leads to the dimerization of the cytoplasmic TIR domains. The activated TLR4 subsequently recruits the adaptor protein complex containing both TICAM-1 and TICAM-2, resulting in the activation of IFN response factors and production of pro-inflammatory cytokines. In this signaling cascade, TICAM-2 is essential for bridging the interaction between TLR4 and TICAM-1. TICAM-2 is also involved in the regulation of the IL-18 signaling pathway, acting as a sorting adaptor that recruits MYD88 from the cytosol to the membrane region upon activation of IL-1/IL-18 receptors.
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途径
- TLR signaling, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Toll-Like Receptors Cascades
抗原
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