T-Bet 抗体
Quick Overview for T-Bet 抗体 (ABIN2665380)
抗原
See all T-Bet 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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纯化方法
 - The antibody was purified by affinity chromatography.
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亚型
 - IgG1 kappa
 
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应用备注
 - Optimal working dilution should be determined by the investigator.
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限制
 - 仅限研究用
 
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浓度
 - 1.0 mg/mL
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缓冲液
 - Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide and EDTA.
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储存液
 - Sodium azide
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注意事项
 - This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
 - 4 °C
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储存方法
 - The antibody solution should be stored undiluted between 2°C and 8°C.
 
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- T-Bet
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背景
 - T-bet, also known as T-box transcription factor T-bet, is considered to be a "master regulator" of Th1 lymphoid development controlling the production of the cytokine IFN-γ. T-bet is widely expressed in hematopoietic cells including stem cells, NK cells, B cells, and T cells. T-bet is critical for the control of microbial pathogens, and knockout animals show multiple physiologic and inflammatory features characteristic of asthma. T-bet expression is optimally observed after IL-12 stimulation and can be suppressed by addition of the Th2 cytokine IL-4 or neutralization of IL-12.
 
抗原
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