NLRP12 抗体
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北京 101111
Quick Overview for NLRP12 抗体 (ABIN2665297)
抗原
See all NLRP12 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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纯化方法
- The antibody was purified by affinity chromatography.
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亚型
- IgG2b kappa
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anti-NLR Family, Pyrin Domain Containing 12 (NLRP12) (AA 1-110) antibody
NLRP12 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 4B9 unconjugated
anti-NLR Family, Pyrin Domain Containing 12 (NLRP12) (AA 183-212), (N-Term) antibodyNLRP12 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB33963 unconjugated
anti-NLR Family, Pyrin Domain Containing 12 (NLRP12) antibodyNLRP12 适用: 人, 小鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-NLR Family, Pyrin Domain Containing 12 (NLRP12) (AA 183-212) antibodyNLRP12 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-NLR Family, Pyrin Domain Containing 12 (NLRP12) (AA 862-1062) antibodyNLRP12 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-NLR Family, Pyrin Domain Containing 12 (NLRP12) (Internal Region) antibodyVerified NLRP12 适用: 小鼠 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-NLR Family, Pyrin Domain Containing 12 (NLRP12) antibodyNLRP12 适用: 小鼠 WB, ELISA 宿主: 小鼠 Monoclonal 228CT4-1-3 unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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浓度
- 0.5 mg/mL
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缓冲液
- Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- The antibody solution should be stored undiluted between 2°C and 8°C.
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- NLRP12 (NLR Family, Pyrin Domain Containing 12 (NLRP12))
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别名
- NLRP12
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背景
- NLRP12, a member of the Nod-like receptor (NLR) family of proteins, was originally suggested to act as an inflammasome forming component and a modulator of NF-κB signaling. Recent studies revealed that NLRP12 plays anti-inflammatory roles, as NLRP12-deficient mice are more susceptible to chemically induced colitis, and show a more severe infiltration of granulocytes and T cells. The colitis induced in NLRP12-/- mice is associated with increased production of proinflammatory cytokines and activation of both NF-κB and ERK signaling pathways. NLRP12 was reported to attenuate canonical NF-κB signaling by inhibiting IRAK-1 phosphorylation. NLRP12 also down-regulates non-canonical NF-κB signaling through interaction with TRAF3 and the NF-κB inducing kinase NIK.
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途径
- Positive Regulation of Endopeptidase Activity, Inflammasome
抗原
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