M-CSF/CSF1 抗体
Quick Overview for M-CSF/CSF1 抗体 (ABIN2665252)
抗原
See all M-CSF/CSF1 (CSF1) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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纯化方法
- The antibody was purified by affinity chromatography.
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亚型
- IgG2b
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anti-Colony Stimulating Factor 1 (Macrophage) (CSF1) (AA 33-204) antibody
CSF1 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Colony Stimulating Factor 1 (Macrophage) (CSF1) antibodyCSF1 适用: 人, 小鼠, 大鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Colony Stimulating Factor 1 (Macrophage) (CSF1) (AA 201-300) antibodyCSF1 适用: 人, 小鼠 WB, ELISA, ICC, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Colony Stimulating Factor 1 (Macrophage) (CSF1) (Middle Region) antibodyCSF1 适用: 人, 小鼠, 大鼠, 犬, Pig, 豚鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Colony Stimulating Factor 1 (Macrophage) (CSF1) (AA 33-132) antibodyCSF1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1A9 unconjugated
anti-Colony Stimulating Factor 1 (Macrophage) (CSF1) (AA 261-427) antibodyCSF1 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Colony Stimulating Factor 1 (Macrophage) (CSF1) (AA 230-257) antibodyCSF1 适用: 人 WB, IF, FACS, IHC (p) 宿主: 兔 Polyclonal RB18764 unconjugated
anti-Colony Stimulating Factor 1 (Macrophage) (CSF1) (C-Term) antibodyCSF1 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Colony Stimulating Factor 1 (Macrophage) (CSF1) (AA 33-554) antibodyCSF1 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Colony Stimulating Factor 1 (Macrophage) (CSF1) antibody (Biotin)CSF1 适用: 人 WB, ELISA, Neut 宿主: 兔 Polyclonal Biotin
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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浓度
- 0.5 mg/mL
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缓冲液
- Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- The antibody solution should be stored undiluted between 2°C and 8°C.
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- M-CSF/CSF1 (CSF1) (Colony Stimulating Factor 1 (Macrophage) (CSF1))
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别名
- M-CSF
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背景
- M-CSF is a cytokine that controls the production, differentiation, and function of macrophages. The active form of the protein is found extracellularly as a disulfide-linked homodimer. M-CSF is released by fibroblasts, breast cancer cell lines, alveolar macrophages, stromal bone marrow cells, endothelial cells, and mesenchymal cells. It binds CD14+ monocytes and promotes the survival/proliferation of human peripheral blood monocytes. In addition, M-CSF enhances inducible monocyte functions including phagocytic activity, microbial killing, cytotoxicity for tumor cells as well as synthesis of inflammatory cytokines such as IL-1, TNF-α, and IFN-γ in monocytes. M-CSF induces RANKL production in mature human osteoclasts and, consequently, this makes M-CSF a potent stimulator of mature osteoclast resorbing activity. Also, M-CSF induces VEGF production in human monocytes and human tumor cells. High levels of M-CSF, mononuclear phagocytes, and VEGF are associated with poor prognosis in patients with cancer.
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途径
- RTK signaling
抗原
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