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IL-34 抗体

IL34 适用: 人 FACS 宿主: 小鼠 Monoclonal E0320E7 unconjugated
产品编号 ABIN2665165
发货至: 中国
  • 抗原 See all IL-34 (IL34) 抗体
    IL-34 (IL34) (Interleukin 34 (IL34))
    适用
    • 38
    • 26
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    宿主
    • 52
    • 8
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    小鼠
    克隆类型
    • 56
    • 8
    单克隆
    标记
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    • 1
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    This IL-34 antibody is un-conjugated
    应用范围
    • 48
    • 31
    • 13
    • 13
    • 13
    • 7
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    Flow Cytometry (FACS)
    纯化方法
    The antibody was purified by affinity chromatography.
    克隆位点
    E0320E7
    亚型
    IgG2b lambda
    Top Product
    Discover our top product IL34 Primary Antibody
  • 应用备注
    Optimal working dilution should be determined by the investigator.
    限制
    仅限研究用
  • 浓度
    0.5 mg/mL
    缓冲液
    Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C
    储存方法
    The antibody solution should be stored undiluted between 2°C and 8°C.
  • 抗原
    IL-34 (IL34) (Interleukin 34 (IL34))
    别名
    IL-34 (IL34 产品)
    别名
    C16orf77 antibody, IL-34 antibody, 2010004A03Rik antibody, AI593503 antibody, C18H16ORF77 antibody, interleukin 34 antibody, IL34 antibody, Il34 antibody
    背景
    Human IL-34 shares a sequence identity of 99.6 % , 72 % and 71 % with chimpanzee, rat, and mouse IL-34, respectively, on the amino acid level. The IL-34 gene is syntenic in the human, chimpanzee, rat, and mouse genomes. IL-34 has no apparent consensus structural domain or motif, and does not share sequence homology with M-CSF, nevertheless, it binds to the CSFR. These two cytokines are not identical in biological activity and signal activation. IL-34 and CSF show an equivalent ability to support cell growth or survival. However, these cytokines are differing in their ability to induce the production of chemokines (MCP-1 and eotaxin-2) in primary macrophages, the morphological change in TF-1-fms cells, and the migration of J774A.1 cells. The use of monoclonal antibodies against the CSFR suggests differential domain binding of the receptor to IL-34 and CSF and as a result, different bioactivities and signal activation kinetics/strength are produced for these cytokines.
    途径
    RTK signaling
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