IL21 Receptor 抗体
Quick Overview for IL21 Receptor 抗体 (ABIN2664615)
抗原
See all IL21 Receptor (IL21R) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
-
-
交叉反应
- Cynomolgus, 猕猴
-
纯化方法
- The antibody was purified by affinity chromatography.
-
亚型
- IgG1 kappa
-
-
anti-Interleukin 21 Receptor (IL21R) (AA 20-232) antibody
IL21R 适用: 人 ELISA, FACS 宿主: 小鼠 Monoclonal 8H10G4D12 unconjugated
anti-Interleukin 21 Receptor (IL21R) (AA 20-240) antibodyIL21R 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Interleukin 21 Receptor (IL21R) (AA 441-538) antibodyIL21R 适用: 小鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Interleukin 21 Receptor (IL21R) (AA 20-240) antibodyIL21R 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Interleukin 21 Receptor (IL21R) (AA 131-165) antibodyIL21R 适用: 人 WB 宿主: 兔 Polyclonal RB54166 unconjugated
anti-Interleukin 21 Receptor (IL21R) (AA 65-80) antibodyIL21R 适用: 人, 猴 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Interleukin 21 Receptor (IL21R) antibodyIL21R 适用: 人 ELISA, FACS 宿主: 兔 Chimeric unconjugated Fc fragment
anti-Interleukin 21 Receptor (IL21R) (AA 23-185) antibodyIL21R 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Interleukin 21 Receptor (IL21R) (Extracellular Domain) antibodyIL21R 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Interleukin 21 Receptor (IL21R) (Extracellular Domain) antibodyIL21R 适用: 人, 小鼠, 大鼠 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
-
-
应用备注
- Optimal working dilution should be determined by the investigator.
-
限制
- 仅限研究用
-
-
-
浓度
- 0.5 mg/mL
-
缓冲液
- Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- 4 °C
-
储存方法
- The antibody solution should be stored undiluted between 2°C and 8°C.
-
-
- IL21 Receptor (IL21R) (Interleukin 21 Receptor (IL21R))
-
别名
- CD360
-
背景
- The human interleukin 21 receptor (IL-21R), is a single pass type I membrane protein and a member of the type I cytokine receptor family. Of the type I cytokine receptors, IL-21R exhibits the greatest extracellular homology to the IL-2R beta subunit, i.e., contains one copy of the WSXWS-containing cytokine-binding domain. Intracellular domains of IL-21R include the Box 1 and Box 2 elements which are similar to the IL-9R intracellular region. Upon binding IL-21, the IL-21R forms a heterodimer with the common gamma subunit (CD132) and induces Jak/Stat signaling. IL-21R is expressed on B cells and at various levels on NK and T cells. IL-21 is a potent immunomodulatory cytokine mainly produced by NKT and CD4 T-cells (particularly the inflammatory Th17 subset) and has pleiotropic effects on both innate and adaptive immune responses. These actions include positive effects such as enhanced proliferation of natural killer (NK) cells and cytotoxic T cells that can destroy virally infected or cancerous cells and direct inhibitory effects on the antigen-presenting function of dendritic cells. It can also be proapoptotic for B cells and NK cells. Recent studies have shown that IL-21 is also an autocrine cytokine that potently induces Th17 differentiation and suppresses Foxp3 expression, and serves as a target for treating inflammatory diseases.
-
途径
- JAK/STAT Signaling
抗原
-
