DC-SIGN/CD209 抗体
Quick Overview for DC-SIGN/CD209 抗体 (ABIN2664393)
抗原
See all DC-SIGN/CD209 (CD209) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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                                            交叉反应
- Macaque
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                                            纯化方法
- The antibody was purified by affinity chromatography.
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                                            亚型
- IgG2b kappa
 
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                                            应用备注
- Optimal working dilution should be determined by the investigator.
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                                            限制
- 仅限研究用
 
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                                            浓度
- 0.5 mg/mL
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                                            缓冲液
- Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
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                                            储存液
- Sodium azide
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                                            注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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                                            储存条件
- 4 °C
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                                            储存方法
- The antibody solution should be stored undiluted between 2°C and 8°C.
 
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    - DC-SIGN/CD209 (CD209) (CD209)
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                                            别名
- CD209
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                                            背景
- CD209, known as Dendritic Cell-Specific Intercellular adhesion molecule 3 (ICAM-3)-Grabbing Nonintegrin (DC-SIGN), is a 44 kD type II transmembrane glycoprotein and a member of the C-type lectin family. CD209 is expressed on myeloid dendritic cells, placental macrophages, liver and placental endothelial cells. CD209 binds to ICAM-3 (CD50), ICAM-2 (CD102), and Butyrophilin (BTN2A1), and mediates dendritic cell migration and T cell proliferation. Importantly, CD209 is a receptor of HIV-1 and some other viruses (such as West Nile virus, hepatitis C virus, etc), and some bacteria or parasites. It plays a criti-cal role in capturing and internalizing those pathogens. LSP1 (leukocyte-specific protein 1) interacts with the cytoplasmic domain of CD209 and mediates transport of HIV to the proteasome.
 抗原
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