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OPRD1 抗体 (PE)

The 小鼠 单克隆 anti-OPRD1 antibody is suitable to detect OPRD1 in samples from 人. It has been validated for FACS 和 IF.
产品编号 ABIN2663677
发货至: 中国
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中国
北京 101111
No. 88 KeChuang 6th Street
Beijing Economic Technological Development Area
Room 801-803
4A Biotech Co.,Ltd.
Tel +86 (0512) 65829739 传真 +86 (010) 6788 5057

Quick Overview for OPRD1 抗体 (PE) (ABIN2663677)

抗原

See all OPRD1 抗体
OPRD1 (Opioid Receptor, delta 1 (OPRD1))

适用

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宿主

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小鼠

克隆类型

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单克隆

标记

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This OPRD1 antibody is conjugated to PE

应用范围

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Flow Cytometry (FACS), Immunofluorescence (IF)

克隆位点

DOR7D2A4
  • 纯化方法

    The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions. The solution is free of unconjugated PE and unconjugated antibody.

    亚型

    IgG2b kappa
  • 应用备注

    Optimal working dilution should be determined by the investigator.

    限制

    仅限研究用
  • 缓冲液

    Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide and 0.2 % (w/v) BSA .

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    注意事项

    Protect from prolonged exposure to light. Do not freeze.

    储存条件

    4 °C

    储存方法

    The antibody solution should be stored undiluted between 2°C and 8°C.
  • 抗原

    OPRD1 (Opioid Receptor, delta 1 (OPRD1))

    别名

    delta Opioid Receptor

    背景

    Opioid receptors are the members of seven transmembrane G-protein coupled receptors. At least 3 types of opioid receptors, μ, κ, and δ, have been identified. Human δ-opioid receptor, know as OPRD, DOR, or hDOR, is primarily expressed in brain, especially in the areas of cortex, including olfactory bulb, hippocampus, and amygdale, as well as in basal ganglia and hypothalamus. Human OPRD gene has been mapped at chromosome 1p34.3-p36.1. The endogenous ligands for the OPRD are enkephalins. The third extracellular loop of the OPRD is critical for ligand binding. The ligands binding and signal transduction functions of δ-receptor can be synergized by forming heterodimers with κ-receptor. Activation of opioid receptor inhibits cAMP production, increases phosphodiesterase activity, and results in analgesia and convulsions. Recent studies have indicated that OPRD is involved in the mechanism of heroin dependence.

    途径

    Protein targeting to Nucleus
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