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PD-L1 抗体 (Biotin)

PD-L1 适用: 小鼠 WB, FACS, IHC, IP, CMCD, CyTOF 宿主: 大鼠 Monoclonal 10F-9G2 Biotin
产品编号 ABIN2661024
发货至: 中国
  • 抗原 See all PD-L1 抗体
    PD-L1 (CD274 (PD-L1))
    适用
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    小鼠
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    大鼠
    克隆类型
    • 112
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    单克隆
    标记
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    This PD-L1 antibody is conjugated to Biotin
    应用范围
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    Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (IHC), Immunoprecipitation (IP), Complement Mediated Cell Depletion (CMCD), Cytometry by Time of Flight (CyTOF)
    纯化方法
    The antibody was purified by affinity chromatography, and conjugated with biotin under optimal conditions. The solution is free of unconjugated biotin.
    克隆位点
    10F-9G2
    亚型
    IgG2b kappa
    Top Product
    Discover our top product PD-L1 Primary Antibody
  • 应用备注
    Optimal working dilution should be determined by the investigator.
    限制
    仅限研究用
  • 浓度
    0.5 mg/mL
    缓冲液
    Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Do not freeze.
    储存条件
    4 °C
    储存方法
    The antibody solution should be stored undiluted between 2°C and 8°C.
  • 抗原
    PD-L1 (CD274 (PD-L1))
    别名
    CD274 (PD-L1 产品)
    背景
    CD274, also known as B7-H1 or programmed death ligand 1 (PD-L1), is a 40 kD type I transmembrane protein and a member of the B7 family within the immunoglobulin receptor superfamily. It is expressed on T cells, B cells, NK cells, dendritic cells, IFN-γ activated endothelial cells, and monocytes. B7-H1 is one of the ligands of PD-1. The interaction of B7-H1 with PD-1 plays an important role in the inhibition of T cell responses. Other studies have shown that B7-H1 is able to costimulate T cell growth and cytokine production. CD274 is involved in costimulation essential for T cell proliferation and production of IL-10 and IFN-γ, in an IL-2-dependent and a PD-1-independent manner. Its interaction with PD-1 inhibits T cell proliferation and cytokine production.
    途径
    Cancer Immune Checkpoints
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