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PD-L1 抗体 (Biotin)

This Biotin-conjugated 大鼠 单克隆 anti-PD-L1 antibody (Clone 10F-9G2) specifically detects PD-L1 in WB, FACS, IHC, IP, CyTOF 和 CMCD. The antibody is reactive with 小鼠 samples.
产品编号 ABIN2661023
发货至: 中国
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中国
北京 101111
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Beijing Economic Technological Development Area
Room 801-803
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Tel +86 (0512) 65829739 传真 +86 (010) 6788 5057

Quick Overview for PD-L1 抗体 (Biotin) (ABIN2661023)

抗原

See all PD-L1 抗体
PD-L1 (CD274 (PD-L1))

适用

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小鼠

宿主

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大鼠

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单克隆

标记

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This PD-L1 antibody is conjugated to Biotin

应用范围

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Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (IHC), Immunoprecipitation (IP), Cytometry by Time of Flight (CyTOF), Complement Mediated Cell Depletion (CMCD)

克隆位点

10F-9G2
  • 纯化方法

    The antibody was purified by affinity chromatography, and conjugated with biotin under optimal conditions. The solution is free of unconjugated biotin.

    亚型

    IgG2b kappa
  • 应用备注

    Optimal working dilution should be determined by the investigator.

    限制

    仅限研究用
  • 浓度

    0.5 mg/mL

    缓冲液

    Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    注意事项

    Do not freeze.

    储存条件

    4 °C

    储存方法

    The antibody solution should be stored undiluted between 2°C and 8°C.
  • 抗原

    PD-L1 (CD274 (PD-L1))

    别名

    CD274

    背景

    CD274, also known as B7-H1 or programmed death ligand 1 (PD-L1), is a 40 kD type I transmembrane protein and a member of the B7 family within the immunoglobulin receptor superfamily. It is expressed on T cells, B cells, NK cells, dendritic cells, IFN-γ activated endothelial cells, and monocytes. B7-H1 is one of the ligands of PD-1. The interaction of B7-H1 with PD-1 plays an important role in the inhibition of T cell responses. Other studies have shown that B7-H1 is able to costimulate T cell growth and cytokine production. CD274 is involved in costimulation essential for T cell proliferation and production of IL-10 and IFN-γ, in an IL-2-dependent and a PD-1-independent manner. Its interaction with PD-1 inhibits T cell proliferation and cytokine production.

    途径

    Cancer Immune Checkpoints
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