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IL7R 抗体 (PE/Dazzle™ 594)

This anti-IL7R antibody is a 小鼠 单克隆 antibody detecting IL7R in FACS, IHC, IP, BR, CyTOF 和 St. Suitable for 人.
产品编号 ABIN2659645
发货至: 中国

Quick Overview for IL7R 抗体 (PE/Dazzle™ 594) (ABIN2659645)

抗原

See all IL7R 抗体
IL7R (Interleukin 7 Receptor (IL7R))

适用

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宿主

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小鼠

克隆类型

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单克隆

标记

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This IL7R antibody is conjugated to PE/Dazzle™ 594

应用范围

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Flow Cytometry (FACS), Immunohistochemistry (IHC), Immunoprecipitation (IP), Blocking Reagent (BR), Cytometry by Time of Flight (CyTOF), Stimulation (St)

克隆位点

A019D5
  • 纯化方法

    The antibody was purified by affinity chromatography and conjugated with PE/Dazzle™ 594 under optimal conditions. The solution is free of unconjugated PE/Dazzle™ 594 and unconjugated antibody.

    亚型

    IgG1 kappa
  • 应用备注

    Optimal working dilution should be determined by the investigator.

    限制

    仅限研究用
  • 缓冲液

    Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide and 0.2 % (w/v) BSA .

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    注意事项

    Protect from prolonged exposure to light. Do not freeze.

    储存条件

    4 °C

    储存方法

    The antibody solution should be stored undiluted between 2°C and 8°C.
  • 抗原

    IL7R (Interleukin 7 Receptor (IL7R))

    别名

    CD127

    背景

    CD127 is a 60-90 kD type I transmembrane glycoprotein also known as IL-7 receptor α chain or IL-7Rα. It forms a heterodimer with the common γ chain (γc or CD132) which is shared with the receptors for IL-2, IL-4, IL-9, IL-13, IL-15, and IL-21. CD127 is expressed on immature B cells through early pre-B stage cells, thymocytes (except CD4/CD8 double positive thymocytes), peripheral T cells, and bone marrow stromal cells. CD127 has been reported to be a useful marker for identifying memory and effector T cells. Studies have shown that CD127 expression is down-modulated on Treg cells. It can be used as a marker for differentiation of Treg and conventional T cells. The ligation of IL-7 with its receptor is important for stimulation of mature and immature T cells as well as immature B cell proliferation and development.

    途径

    JAK/STAT Signaling, Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response, Regulation of Cell Size
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