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IKZF3 抗体 (Alexa Fluor 647)

This anti-IKZF3 antibody is a 小鼠 单克隆 antibody detecting IKZF3 in FACS. Suitable for 小鼠.
产品编号 ABIN2657113
发货至: 中国

Quick Overview for IKZF3 抗体 (Alexa Fluor 647) (ABIN2657113)

抗原

See all IKZF3 抗体
IKZF3 (IKAROS Family Zinc Finger 3 (Aiolos) (IKZF3))

适用

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小鼠

宿主

  • 54
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小鼠

克隆类型

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单克隆

标记

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This IKZF3 antibody is conjugated to Alexa Fluor 647

应用范围

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Flow Cytometry (FACS)

克隆位点

8B2
  • 无交叉反应

    小鼠

    纯化方法

    The antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 647 under optimal conditions.

    亚型

    IgG1 kappa, IgG
  • 应用备注

    Optimal working dilution should be determined by the investigator.

    限制

    仅限研究用
  • 浓度

    0.5 mg/mL

    缓冲液

    Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    注意事项

    Protect from prolonged exposure to light. Do not freeze.

    储存条件

    4 °C

    储存方法

    The antibody solution should be stored undiluted between 2°C and 8°C
  • 抗原

    IKZF3 (IKAROS Family Zinc Finger 3 (Aiolos) (IKZF3))

    别名

    Aiolos

    背景

    Aiolos, an Ikaros family member, is also known as Izkf3. It has a molecular weight of 58 kD and shows 70 % homology to the Ikaros isoform, Ik-1, particularly in the DNA binding and C-terminal domains. Aiolos can form a heteromer with Ikaros or exist as a homodimer. The homomeric complex is a potent transcriptional activator. Unlike Ikaros, Aiolos is expressed in late fetal thymus and adult lymphoid organs. Among the adult hematopoietic progenitors, Aiolos is expressed at low levels in mulitpotent but not in pluripotent stem cells. When these multipotent progenitors become more restricted to T and B lymphoid pathways there is an upregulation in Aiolos expression. The highest expression of Aiolos is detected in the spleen (especially in B-cells) followed by thymus and bone marrow, and cannot be detected in the non-lymphoid organs. Aiolos plays an important role in lymphocyte proliferation and differentiation.
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