HDAC8 抗体
Quick Overview for HDAC8 抗体 (ABIN265460)
抗原
See all HDAC8 抗体适用
宿主
克隆类型
标记
应用范围
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特异性
- This antibody detects endogenous levels of HDAC8 protein. (region surrounding Lys33)
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交叉反应 （详细）
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Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human. -
纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
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纯度
- > 95 % pure by SDS-PAGE
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anti-Histone Deacetylase 8 (HDAC8) antibody
KO Validated HDAC8 适用: 人 WB, IHC, IF, IP 宿主: 兔 Monoclonal unconjugated
anti-Histone Deacetylase 8 (HDAC8) (AA 1-377) antibodyHDAC8 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 2F4 unconjugated
anti-Histone Deacetylase 8 (HDAC8) (AA 1-100) antibodyHDAC8 适用: 人 WB, ELISA, IP 宿主: 小鼠 Monoclonal 2F4 unconjugated
anti-Histone Deacetylase 8 (HDAC8) (pSer39) antibodyHDAC8 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Histone Deacetylase 8 (HDAC8) antibodyHDAC8 适用: 人, 小鼠, 大鼠 WB, IF (cc), IHC (p) 宿主: 兔 Monoclonal 4C3 unconjugated
anti-Histone Deacetylase 8 (HDAC8) (AA 1-377) antibodyHDAC8 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Histone Deacetylase 8 (HDAC8) antibodyHDAC8 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Histone Deacetylase 8 (HDAC8) (C-Term) antibodyHDAC8 适用: 人, 小鼠, 大鼠, 猴, Cow, 兔, 马 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Histone Deacetylase 8 (HDAC8) (N-Term) antibodyHDAC8 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Histone Deacetylase 8 (HDAC8) (AA 151-250) antibodyHDAC8 适用: 人, 小鼠 ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
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应用备注
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ELISA: 1: 20000approx. 1: 40000. WB: 1: 500approx. 1: 1000. IHC: 1: 50approx. 1: 200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- Phosphate buffered saline (PBS), pH 7.2., 15 mM sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- DO NOT FREEZE!
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储存条件
- 4 °C
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储存方法
- Store the antibody undiluted at 2-8 °C.
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- HDAC8 (Histone Deacetylase 8 (HDAC8))
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别名
- HDAC8
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背景
- In the intact cell, DNA closely associates with histones and other nuclear proteins to form chromatin. The remodeling of chromatin is believed to be a critical component of transcriptional regulation and a major source of this remodeling is brought about by the acetylation of nucleosomal histones. Acetylation of lysine residues in the amino terminal tail domain of histone results in an allosteric change in the nucleosomal conformation and an increased accessibility to transcription factors by DNA. Conversely, the deacetylation of histones is associated with transcriptional silencing. Several mammalian proteins have been identified as nuclear histone acetylases, including GCN5, PCAF (p300/CBP-associated factor), p300/CBP, HAT1 and the TFIID subunit TAF II p250. Mammalian HDAC8, isolated from human kidney, is a histone deacetylase that shares homology to other HDACs but has different tissue distribution. HDAC8 is localized to the nucleus and plays a role in the development of a broad range of tissues and in the etiology of cancer.Synonyms: CDA07, HD8, HDACL1, Histone deacetylase 8
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分子量
- approx. 45 kDa
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基因ID
- 55869
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NCBI登录号
- NP_001159890
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UniProt
- Q9BY41
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途径
- Cellular Glucan Metabolic Process
抗原
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