TOLLIP 抗体 (C-Term)
Our Local Distributor
北京 101111
Quick Overview for TOLLIP 抗体 (C-Term) (ABIN265153)
抗原
See all TOLLIP 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- C-Term
-
特异性
- This antibody is specific for TOLLIP. Located in the cytoplasm and phosphorylated by IRAK1 upon stimulation by IL-1 or microbial products (5).
-
纯化方法
- Purified
-
免疫原
- A 16 amino acid peptide from near the carboxy terminus of human TOLLIP
-
亚型
- IgG
-
-
-
-
应用备注
-
Western Blot: 1 μg/mL. Positive Control: Rat Brain Lysate. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
-
-
-
缓冲液
- Phosphate buffered saline with 0.02 % sodium azide
-
储存液
- Sodium azide
-
注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
注意事项
- Avoid repeated freezing and thawing.
-
储存条件
- -20 °C
-
储存方法
- Store the antibody (in aliquots) at -20 °C. Can be shipped at 2 - 8 °C.
-
-
- TOLLIP (Toll Interacting Protein (TOLLIP))
-
别名
- TOLLIP
-
背景
- Toll-like receptors (TLRs) are evolutionarily conserved pattern-recognition molecules resembling the toll proteins that mediate antimicrobial responses in Drosophila. These proteins recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses (1,2). The TLRs act through adaptor molecules to activate various kinases and transcription factors (3) so the organism can respond to potential infection. These adaptor molecules include TOLLIP, MyD88, and TRIF. TOLLIP associates directly with TLR2 and TLR 4, acting as an inhibitor to TLR activation (4). This negative regulation of TLR signaling may serve to limit the production of proinflammatory mediators during infection and inflammation.Synonyms: Toll-interacting protein
-
基因ID
- 54472
-
NCBI登录号
- NP_061882
-
UniProt
- Q9H0E2
抗原
-