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TOLLIP 抗体 (C-Term)

This 兔 多克隆 antibody specifically detects TOLLIP in WB 和 IHC (fro). It exhibits reactivity toward 人, 小鼠 和 大鼠.
产品编号 ABIN265153
发货至: 中国
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Quick Overview for TOLLIP 抗体 (C-Term) (ABIN265153)

抗原

See all TOLLIP 抗体
TOLLIP (Toll Interacting Protein (TOLLIP))

适用

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人, 小鼠, 大鼠

宿主

  • 57
  • 12
  • 2

克隆类型

  • 60
  • 12
多克隆

标记

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This TOLLIP antibody is un-conjugated

应用范围

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Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro))
  • 抗原表位

    • 15
    • 8
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    • 3
    • 3
    • 3
    • 2
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    C-Term

    特异性

    This antibody is specific for TOLLIP. Located in the cytoplasm and phosphorylated by IRAK1 upon stimulation by IL-1 or microbial products (5).

    纯化方法

    Purified

    免疫原

    A 16 amino acid peptide from near the carboxy terminus of human TOLLIP

    亚型

    IgG
  • 应用备注

    Western Blot: 1 μg/mL. Positive Control: Rat Brain Lysate. Immunohistochemistry.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.

    限制

    仅限研究用
  • 缓冲液

    Phosphate buffered saline with 0.02 % sodium azide

    储存液

    Sodium azide

    注意事项

    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    注意事项

    Avoid repeated freezing and thawing.

    储存条件

    -20 °C

    储存方法

    Store the antibody (in aliquots) at -20 °C. Can be shipped at 2 - 8 °C.
  • 抗原

    TOLLIP (Toll Interacting Protein (TOLLIP))

    别名

    TOLLIP

    背景

    Toll-like receptors (TLRs) are evolutionarily conserved pattern-recognition molecules resembling the toll proteins that mediate antimicrobial responses in Drosophila. These proteins recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses (1,2). The TLRs act through adaptor molecules to activate various kinases and transcription factors (3) so the organism can respond to potential infection. These adaptor molecules include TOLLIP, MyD88, and TRIF. TOLLIP associates directly with TLR2 and TLR 4, acting as an inhibitor to TLR activation (4). This negative regulation of TLR signaling may serve to limit the production of proinflammatory mediators during infection and inflammation.Synonyms: Toll-interacting protein

    基因ID

    54472

    NCBI登录号

    NP_061882

    UniProt

    Q9H0E2
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