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TLR5 抗体 (C-Term)

The 兔 多克隆 anti-TLR5 antibody is suitable to detect TLR5 in samples from 人 和 小鼠. It has been validated for WB 和 IF.
产品编号 ABIN265142
发货至: 中国
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Tel +86 (0512) 65829739 传真 +86 (010) 6788 5057

Quick Overview for TLR5 抗体 (C-Term) (ABIN265142)

抗原

See all TLR5 抗体
TLR5 (Toll-Like Receptor 5 (TLR5))

适用

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人, 小鼠

宿主

  • 94
  • 17
  • 3

克隆类型

  • 87
  • 27
多克隆

标记

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This TLR5 antibody is un-conjugated

应用范围

  • 89
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  • 36
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Western Blotting (WB), Immunofluorescence (IF)
  • 抗原表位

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    C-Term

    特异性

    This antibody detects TLR5.

    纯化方法

    Purified

    免疫原

    Peptide corresponding to 15 amino acids near the carboxy terminus of human TLR5

    亚型

    IgG
  • 应用备注

    Western Blot: 1-2 μg/mL. Immunocytochemistry.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.

    限制

    仅限研究用
  • 缓冲液

    Phosphate buffered saline with 0.02 % Sodium Azide as preservative.

    储存液

    Sodium azide

    注意事项

    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    注意事项

    Avoid repeated freezing and thawing.

    储存条件

    -20 °C

    储存方法

    Store the antibody (in aliquots) at -20 °C. Can be shipped at 2-8 °C.
  • 抗原

    TLR5 (Toll-Like Receptor 5 (TLR5))

    别名

    TLR5

    背景

    Toll-like receptors (TLRs) are evolutionarily conserved pattern-recognition molecules resembling the toll proteins that mediate antimicrobial responses in Drosophila. These proteins recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses (1,2). The TLRs act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors (3) so the organism can respond to potential infection. TLR5 recognizes flagellin from both Gram-positive and Gram-negative bacteria and will cause the activation of NF-κB, leading to the activation of TNF-? and other cytokines (4). A common TLR5 stop codon polymorphism that disrupts TLR5 signaling is associated with susceptibility to Legionnaires' disease and demonstrates the importance of TLR5 in the innate immune response (5). Found in the membrane, TLR5 is hghly expressed in ovary and in peripheral blood leukocytes, especially in monocytes, less in CD11c+ immature dendritic cells. Also detected in prostate and testis (6).Synonyms: TIL3, Toll-like receptor 5, Toll/interleukin-1 receptor-like protein 3

    基因ID

    7100

    NCBI登录号

    NP_003259

    UniProt

    O60602

    途径

    TLR signaling, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Toll-Like Receptors Cascades
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