MTA2 抗体 (AA 652-668)
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北京 101111
Quick Overview for MTA2 抗体 (AA 652-668) (ABIN265128)
抗原
See all MTA2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 652-668
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特异性
- This antibody reacts to MTA2 / PID. No cross response to MTA1.
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纯化方法
- Purified
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免疫原
- Rabbit polyclonal PID antibody was raised against a synthetic peptide corresponding to amino acids 652 to 668 of human PID/MTA2 (6), which differ from the mouse sequence by one amino acid (7).
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亚型
- IgG
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anti-Metastasis Associated 1 Family, Member 2 (MTA2) antibody
MTA2 适用: 人 WB, IHC, IF, ChIP 宿主: 兔 Monoclonal unconjugated
anti-Metastasis Associated 1 Family, Member 2 (MTA2) (AA 60-180) antibodyMTA2 适用: 人 WB, ChIP 宿主: 兔 Polyclonal unconjugated
anti-Metastasis Associated 1 Family, Member 2 (MTA2) antibodyKD Validated MTA2 适用: 人 WB, ICC, FACS 宿主: 兔 Monoclonal 24GB400 unconjugated Recombinant Antibody
anti-Metastasis Associated 1 Family, Member 2 (MTA2) (C-Term) antibodyMTA2 适用: 人, Cow, 马, 兔, 山羊, Bat, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Metastasis Associated 1 Family, Member 2 (MTA2) (C-Term) antibodyMTA2 适用: 人 WB, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Metastasis Associated 1 Family, Member 2 (MTA2) (AA 1-394) antibodyMTA2 适用: 人 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Metastasis Associated 1 Family, Member 2 (MTA2) (AA 516-544), (C-Term) antibodyMTA2 适用: 人, 小鼠 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB20031 unconjugated
anti-Metastasis Associated 1 Family, Member 2 (MTA2) (C-Term) antibodyMTA2 适用: 人, 小鼠, 大鼠, 犬, Cow, 马, 兔, 山羊, 豚鼠, Pig WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Metastasis Associated 1 Family, Member 2 (MTA2) (AA 398-447) antibodyMTA2 适用: 人, 斑马鱼, 非洲爪蟾 WB 宿主: 兔 Polyclonal unconjugated
anti-Metastasis Associated 1 Family, Member 2 (MTA2) (C-Term) antibodyMTA2 适用: 人, 小鼠, 大鼠, 犬, Cow, 马, 兔, 豚鼠, Pig, Bat, 猴 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western Blot: 0.5 to 1 μg/mL, a 75 kDa band can be detected. Tissue Expression: Widely expressed, located in the nucleus. Positive Control: HeLa cell lysate. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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缓冲液
- Phosphate buffered saline with 0.02 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- -20 °C
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储存方法
- The antibody can be shipped at ambient temperature. Store (in aliquots) at -20 °C only.
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- MTA2 (Metastasis Associated 1 Family, Member 2 (MTA2))
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别名
- MTA2
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背景
- The p53 tumor-suppressor gene integrates numerous signals that control cell life and death. Several novel molecules involved in p53 pathway, including Chk2 , p53R2 (2), p53AIP1 (3), Noxa (4), PIDD (5), and PID/MTA2 (6), were recently discovered. The transcriptional activity of p53 is modulated by protein stability and acetylation. PID/MTA2, also termed MTA1-L1, was found to be a subunit of nucleosome remodeling and deacetylating (NRD/NuRD) complex (6 - 8). PID/MTA2 modulates the enzymatic activity of the histone deacetylase complex and its expression reduces the levels of acetylated p53. Deacetylation of p53 by PID/MTA2 represses p53-dependent transcriptional activation and modulates p53-mediated cell growth arrest and apoptosis (6). PID/MTA2 is ubiquitously expressed in human tissues (8).Synonyms: MTA1-L1, MTA1L1, Metastasis-associated 1-like 1, Metastasis-associated protein MTA2, PID, p53 target protein in deacetylase complex
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基因ID
- 9219
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NCBI登录号
- NP_004730
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UniProt
- O94776
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途径
- Chromatin Binding
抗原
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