Clusterin 抗体 (Isoform 1)
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Quick Overview for Clusterin 抗体 (Isoform 1) (ABIN265125)
抗原
See all Clusterin (CLU) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Isoform 1
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特异性
- This antibody reacts to Apolipoprotein J (Clusterin).
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纯化方法
- Purified
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免疫原
- Rabbit polyclonal Clusterin antibody was raised recombinant human Clusterin isoform 1.
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亚型
- IgG
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anti-Clusterin (CLU) (AA 331-449) antibody
CLU 适用: 人, 大鼠, 小鼠 ELISA, IHC (p), FACS, IHC (fro), IF (p), IF (cc) 宿主: 兔 Polyclonal unconjugated
anti-Clusterin (CLU) (AA 229-446) antibodyCLU 适用: Pig WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Clusterin (CLU) (AA 227-448) antibodyCLU 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Clusterin (CLU) (AA 228-449) antibodyCLU 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Clusterin (CLU) (AA 226-447) antibodyCLU 适用: 兔 WB, IHC, IP, ICC 宿主: 小鼠 Monoclonal C10 unconjugated
anti-Clusterin (CLU) (C-Term) antibodyVerified CLU 适用: 人 WB, IHC, ELISA, IF 宿主: 山羊 Polyclonal unconjugated
anti-Clusterin (CLU) (AA 23-120) antibodyCLU 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Clusterin (CLU) (AA 71-99), (N-Term) antibodyCLU 适用: 人, 大鼠, 小鼠 WB, IHC (p), FACS 宿主: 兔 Polyclonal RB18701 unconjugated
anti-Clusterin (CLU) (AA 227-447) antibodyCLU 适用: 大鼠 WB, IHC 宿主: 小鼠 Monoclonal C1 unconjugated
anti-Clusterin (CLU) (C-Term) antibodyVerified CLU 适用: 大鼠, 小鼠 WB, ELISA, IF 宿主: 山羊 Polyclonal unconjugated
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应用备注
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Western Blot: 0.5 - 1 μg/mL. Positive Control: Human Brain Tissue Lysate used as positive control. Clusterin is known tobe expressed in a variety of tissues and it seems to be able to bind to cells, membranesand hydrophobic proteins.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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缓冲液
- Phosphate buffered saline with 0.02 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- -20 °C
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储存方法
- The antibody can be shipped at ambient temperature. Store (in aliquots) at -20 °C only.
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- Clusterin (CLU)
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别名
- Apolipoprotein J (Apo J)
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背景
- Clusterin, also known as Apolipoprotein J (ApoJ), is a ubiquitous multifunctional glycoprotein that can interact with a broad spectrum of molecules such as complement components, various receptors, and the Alzheimer's b-amyloid peptide (1). Clusterin expression is increased in Alzheimer's disease brain tissue and clusterinimmunoreactive amyloid plaques are found associated with phospho-tau-positive dystrophic neurites (2) and it has been suggested that clusterin facilitates the conversion of diffuse bamyloid deposits into amyloid and enhances tau phosphorylation in neurites around these plaques. Other reports show that clusterin expression is decreased in proliferating cells and is upregulated in quiescent and senescent cells, suggesting that it may also play a role in aging and tumorigenesis suppression (3). Clusterin exists in at least two distinct isoforms.Synonyms: 40, 40, AAG4, APOJ, Aging-associated gene 4 protein, CLI, Clusterin, Complement cytolysis inhibitor, Complement-associated protein SP-40, KUB1, Ku70-binding protein 1, NA1/NA2, SP-40, Testosterone-repressed prostate message 2
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基因ID
- 1191
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NCBI登录号
- NP_976084
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UniProt
- P10909
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途径
- Apoptosis, Negative Regulation of intrinsic apoptotic Signaling
抗原
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