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AKAP12 抗体 (AA 620-1596)

This 绵羊 多克隆 antibody specifically detects AKAP12 in WB, IP 和 IHC (fro). It exhibits reactivity toward 大鼠 和 Cow.
产品编号 ABIN264964
发货至: 中国
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Quick Overview for AKAP12 抗体 (AA 620-1596) (ABIN264964)

抗原

See all AKAP12 抗体
AKAP12 (A Kinase (PRKA) Anchor Protein 12 (AKAP12))

适用

  • 20
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大鼠, Cow

宿主

  • 21
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绵羊

克隆类型

  • 24
  • 1
多克隆

标记

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This AKAP12 antibody is un-conjugated

应用范围

  • 12
  • 9
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  • 5
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Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro))
  • 抗原表位

    • 2
    • 2
    • 2
    • 1
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    • 1
    • 1
    • 1
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    AA 620-1596

    纯化方法

    Ammonium Sulfate Precipitation.

    免疫原

    Recombinant protein corresponding to amino acids 620-1596 of the SSeCKS protein.

    亚型

    IgG
  • 应用备注

    Western Blot: 2-5 μg/mL. Immunoprecipitation. Immunohistochemistry.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.

    限制

    仅限研究用
  • 浓度

    1.0 mg/mL

    缓冲液

    Phosphate buffered saline with 0.08 % Sodium Azide as preservative.

    储存液

    Sodium azide

    注意事项

    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    注意事项

    Avoid repeated freezing and thawing.

    储存条件

    -20 °C

    储存方法

    The antibody can be shipped at ambient temperature. Store (in aliquots) at -20 °C only.
  • 抗原

    AKAP12 (A Kinase (PRKA) Anchor Protein 12 (AKAP12))

    别名

    AKAP12 / SSeCKS

    背景

    Activation of protein kinase C is a key signal transduction event in mesangial cell dedifferentiation and proliferation, yet little is known about downstream substrates or their roles in normal or diseased states. SSeCKS, a novel protein kinase C substrate originally isolated as a src-suppressed negative mitogenic regulator in fibroblasts, controls actinbased cytoskeletal architecture and scaffolds key signaling kinases such as protein kinase C and protein kinase A. Activation of protein kinase C is a key signal transduction event in mesangial cell dedifferentiation. A role for SSeCKS, a PKA/PKC scaffolding protein, has been implicatedduring the process of spermiogenesis and in the actinbased stellate morphology of mesangial cells.

    基因ID

    10116

    UniProt

    Q62766

    途径

    cAMP Metabolic Process
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