AKAP12 抗体 (AA 620-1596)
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北京 101111
Quick Overview for AKAP12 抗体 (AA 620-1596) (ABIN264964)
抗原
See all AKAP12 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 620-1596
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纯化方法
- Ammonium Sulfate Precipitation.
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免疫原
- Recombinant protein corresponding to amino acids 620-1596 of the SSeCKS protein.
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亚型
- IgG
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应用备注
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Western Blot: 2-5 μg/mL. Immunoprecipitation. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- Phosphate buffered saline with 0.08 % Sodium Azide as preservative.
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- -20 °C
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储存方法
- The antibody can be shipped at ambient temperature. Store (in aliquots) at -20 °C only.
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- AKAP12 (A Kinase (PRKA) Anchor Protein 12 (AKAP12))
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别名
- AKAP12 / SSeCKS
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背景
- Activation of protein kinase C is a key signal transduction event in mesangial cell dedifferentiation and proliferation, yet little is known about downstream substrates or their roles in normal or diseased states. SSeCKS, a novel protein kinase C substrate originally isolated as a src-suppressed negative mitogenic regulator in fibroblasts, controls actinbased cytoskeletal architecture and scaffolds key signaling kinases such as protein kinase C and protein kinase A. Activation of protein kinase C is a key signal transduction event in mesangial cell dedifferentiation. A role for SSeCKS, a PKA/PKC scaffolding protein, has been implicatedduring the process of spermiogenesis and in the actinbased stellate morphology of mesangial cells.
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基因ID
- 10116
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UniProt
- Q62766
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途径
- cAMP Metabolic Process
抗原
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