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PPP4R1 抗体 (AA 38-52)

PPP4R1 适用: 人, 小鼠, 大鼠, Cow WB 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN264952
发货至: 中国
  • 抗原 See all PPP4R1 抗体
    PPP4R1 (Protein Phosphatase 4, Regulatory Subunit 1 (PPP4R1))
    抗原表位
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 38-52
    适用
    • 14
    • 7
    • 5
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    人, 小鼠, 大鼠, Cow
    宿主
    • 11
    • 2
    • 1
    克隆类型
    • 13
    • 1
    多克隆
    标记
    • 14
    This PPP4R1 antibody is un-conjugated
    应用范围
    • 10
    • 4
    • 2
    • 2
    • 1
    Western Blotting (WB)
    纯化方法
    Purified
    免疫原
    Antibody raised against synthetic peptide corresponding to amino acids 38 to 52 of the human protein phosphatase 4R1.
    亚型
    IgG
    Top Product
    Discover our top product PPP4R1 Primary Antibody
  • 应用备注
    Western Blot: Detects a 125 kDa band in bovine testes lysate.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    限制
    仅限研究用
  • 缓冲液
    Phosphate buffered saline with 0.08 % sodium azide
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid repeated freezing and thawing.
    储存条件
    -20 °C
    储存方法
    The antibody can be shipped at ambient temperature. Store (in aliquots) at -20 °C only.
  • 抗原
    PPP4R1 (Protein Phosphatase 4, Regulatory Subunit 1 (PPP4R1))
    Abstract
    PPP4R1 产品
    背景
    Protein serine/threonine phosphatase 4R1 is a protein which is associated with the catalytic subunit of protein serine/threonine phosphatase 4 (PP4C) and may possibly regulate the activity of the enzyme. PP4C is 65 % identical to PP2AC at the amino acid level and has been placed in the type 2A family of phosphatases. PP4C has been highly conserved between species sharing 91 % amino acid identity between human and Drosophila PP4C is predominantly localized in the nucleus in rat brain and liver but is most highly expressed in testis. Additionally, PP4C was demonstrated to be an essential enzyme in the development of Drosophila embryos. The expression of PP4C was reduced to 25 % of the normal protein level in a mutant strain of Drosophila termed centrosomes minus microtubules (cmm). An interesting characteristic of the cmm phenotype is the presence of regions of cells that are unable to complete mitosis because no microtubules exist to connect chromatin and centrosomes. This phenotype implicates PP4C in the regulation of the nucleation and/or stabilization of microtubules. These data taken together indicate that PP4 has a crucial cellular function, although a physiological substrate for PP4 has not yet been identified.Synonyms: PP4R1, Protein Phosphatase X/A'2
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