PPP4R1 抗体 (AA 38-52)
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北京 101111
Quick Overview for PPP4R1 抗体 (AA 38-52) (ABIN306662)
抗原
See all PPP4R1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 38-52
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原理
- Rabbit anti Human Protein Phosphatase 4 R1 (X/A'2)
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产品特性
- Protein serine/threonine phosphatase 4R1 is a protein which is associated with the catalytic subunit of protein serine/threonine phosphatase 4 (PP4C) and may possibly regulate the activity of the enzyme. PP4C is 65 % identical to PP2AC at the amino acid level and has been placed in the type 2A family of phosphatases. PP4C has been highly conserved between species sharing 91 % amino acid identity between human and Drosophila PP4C is predominantly localized in the nucleus in rat brain and liver but is most highly expressed in testis. Additionally, PP4C was demonstrated to be an essential enzyme in the development of Drosophila embryos. The expression of PP4C was reduced to 25 % of the normal protein level in a mutant strain of Drosophila termed centrosomes minus microtubules (cmm). An interesting characteristic of the cmm phenotype is the presence of regions of cells that are unable to complete mitosis because no microtubules exist to connect chromatin and centrosomes. This phenotype implicates PP4C in the regulation of the nucleation and/or stabilization of microtubules. These data taken together indicate that PP4 has a crucial cellular function, although a physiological substrate for PP4 has not yet been identified.
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纯化方法
- Ammonium Sulfate Precipitation
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免疫原
- Antibody raised against synthetic peptide corresponding to amino acids 38 to 52 of the human protein phosphatase 4R1.
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亚型
- IgG
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anti-Protein Phosphatase 4, Regulatory Subunit 1 (PPP4R1) (AA 324-647) antibody
PPP4R1 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Protein Phosphatase 4, Regulatory Subunit 1 (PPP4R1) (AA 114-348) antibodyPPP4R1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Protein Phosphatase 4, Regulatory Subunit 1 (PPP4R1) (N-Term) antibodyPPP4R1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Protein Phosphatase 4, Regulatory Subunit 1 (PPP4R1) (C-Term) antibodyPPP4R1 适用: 人, 小鼠, 大鼠, 猴 WB, FACS 宿主: 兔 Polyclonal unconjugated
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应用备注
- Detects protein phosphatase X/A (PP4 R1) protein by Western blot. Detects a 125 kDa band in bovine testes lysate. Optimal concentration should be evaluated by serial dilutions.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- phosphate buffered saline with 0.08 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles
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