PLAT 抗体
Our Local Distributor
北京 101111
Quick Overview for PLAT 抗体 (ABIN264767)
抗原
See all PLAT 抗体适用
宿主
克隆类型
标记
应用范围
-
-
特异性
- This antibody recognizes tPA.
-
纯化方法
- Protein A Chromatography
-
免疫原
- Recombinant human tPA
-
-
anti-Plasminogen Activator, Tissue (PLAT) antibody
PLAT 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Plasminogen Activator, Tissue (PLAT) (AA 311-562) antibodyPLAT 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Plasminogen Activator, Tissue (PLAT) antibodyPLAT 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Plasminogen Activator, Tissue (PLAT) (AA 359-532) antibodyPLAT 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Plasminogen Activator, Tissue (PLAT) (AA 371-399) antibodyPLAT 适用: 人, 小鼠, 大鼠 WB, IHC (p), FACS 宿主: 兔 Polyclonal RB18787 unconjugated
anti-Plasminogen Activator, Tissue (PLAT) (AA 371-399) antibodyPLAT 适用: 人 WB, IHC, ELISA, FACS 宿主: 兔 Polyclonal unconjugated
anti-Plasminogen Activator, Tissue (PLAT) (C-Term) antibodyPLAT 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Plasminogen Activator, Tissue (PLAT) antibodyPLAT 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Plasminogen Activator, Tissue (PLAT) (AA 36-126) antibodyPLAT 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Plasminogen Activator, Tissue (PLAT) (AA 485-562) antibodyPLAT 适用: 小鼠, 大鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
-
-
应用备注
-
ELISA: 1: 10,000 - 1: 100,000. Western blot: 1: 1,000 - 1: 10,000. Immunohistochemistry: 1: 100 - 1: 1,000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
-
-
-
浓度
- 4.5 mg/mL (OD280nm, E0.1% = 1.36)
-
缓冲液
- 0.05 M Sodium Phosphate, pH 6.6 containing 0.5 M Sodium Chloride and 1 mM EDTA
-
注意事项
- Avoid repeated freezing and thawing.
-
储存条件
- -80 °C
-
-
- PLAT (Plasminogen Activator, Tissue (PLAT))
-
别名
- T-PA / PLAT
-
背景
- TPA converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond. By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, cell migration and many other physiopathological events. TPA binds to fibrin with high affinity, this leads to an increase in the catalytic efficiency of the enzyme of 100- to 1000-fold, due to an increase in affinity for plasminogen. Similarly, binding to heparin increases the activation of plasminogen. Binding to laminin and fibronectin has also been demonstrated. TPA also binds to mannose receptor and the low density lipoprotein receptor related protein (LRP1). These proteins are involved in TPA clearance. TPA binds to annexin II and to cytokeratin 8. As yet unidentified interactions on endothelial cells and vascular smooth muscle cells (VSMC) lead to a 100-fold stimulation of plasminogen activation. Binding to VSMC reduces TPA inhibition by PAI-1 by 30-fold.Synonyms: Alteplase, Reteplase, Tissue-type plasminogen activator, tPA
-
基因ID
- 5327
-
NCBI登录号
- NP_000921
-
UniProt
- P00750
-
途径
- Autophagy, Smooth Muscle Cell Migration, Platelet-derived growth Factor Receptor Signaling, SARS-CoV-2 Protein Interactome
抗原
-
