FKBP5 抗体
Our Local Distributor
北京 101111
Quick Overview for FKBP5 抗体 (ABIN263962)
抗原
See all FKBP5 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
-
-
特异性
- Detects an ~51 kDa protein representing FKBP51 in HeLa cell lysate. Also detects FKBP51 in whole tissue extracts from rat kidney and rat and mouse testes.
-
产品特性
- Synonyms: AIG6, FK506-binding protein 5, FKBP54, FF1 antigen, Rotamase, Peptidyl-prolyl cis-transisomerase FKBP5, 51 kDa FK506-binding protein, 54 kDa progesterone receptor-associatedimmunophilin, HSP90-binding immunophilin, Androgen-regulated protein 6
-
纯化方法
- Epitope affinity chromatography
-
免疫原
- Synthetic peptide corresponding to the residues of human FKBP51
-
亚型
- IgG
-
-
anti-FK506 Binding Protein 5 (FKBP5) (AA 1-457) antibody
FKBP5 适用: 人 WB, IF, IHC (p) 宿主: 小鼠 Polyclonal unconjugated
anti-FK506 Binding Protein 5 (FKBP5) (AA 308-457) antibodyFKBP5 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-FK506 Binding Protein 5 (FKBP5) antibodyFKBP5 适用: 人 WB, IHC 宿主: 兔 Monoclonal unconjugated
anti-FK506 Binding Protein 5 (FKBP5) antibodyFKBP5 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-FK506 Binding Protein 5 (FKBP5) antibodyFKBP5 适用: 人 WB, ICC, IF 宿主: 小鼠 Monoclonal Hi51B unconjugated
anti-FK506 Binding Protein 5 (FKBP5) (AA 1-457) antibodyFKBP5 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-FK506 Binding Protein 5 (FKBP5) (AA 1-457) antibodyFKBP5 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3D10-1G11 unconjugated
anti-FK506 Binding Protein 5 (FKBP5) (AA 1-457) antibodyFKBP5 适用: 人 WB, IF, ELISA 宿主: 小鼠 Monoclonal 3D1-1B10 unconjugated
anti-FK506 Binding Protein 5 (FKBP5) antibodyKD Validated FKBP5 适用: 人 WB, FACS 宿主: 兔 Monoclonal 25GB2445 unconjugated Recombinant Antibody
anti-FK506 Binding Protein 5 (FKBP5) (AA 201-300) antibodyFKBP5 适用: 小鼠, 大鼠 ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
-
-
应用备注
-
Western blot (1: 2000).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
-
-
-
浓度
- 1.0 mg/mL
-
缓冲液
- PBS containing 50 % glycerol and 0.09 % sodium azide
-
储存液
- Sodium azide
-
注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- 4 °C/-20 °C
-
储存方法
-
Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer. Avoidrepeated freezing and thawing.
Shelf life: one year from despatch. -
有效期
- 12 months
-
-
- FKBP5 (FK506 Binding Protein 5 (FKBP5))
-
别名
- FKBP5 / FKBP51
-
背景
- Hsp90 is crucial to cellular signaling by its regulation of the folding, activity, and stability of a wide range of client proteins. These client protein complexes may also contain one or more cochaperones (1). One class of Hsp90-binding cochaperone is composed of proteins with a characteristic tetratricopeptide repeat (TPR) domain that forms an Hsp90 binding site. Among the TPR cochaperones of Hsp90 are Hop/Sti1, protein phosphatase PP5, and members of both the FK506- and cyclosporin A-binding families of immunophilins (2). FK506-binding protein 51 (FKBP51) and FKBP52 are large molecular weight immunophilins that are part of the mature glucocorticoid receptor (GR) heterocomplex (3). The N terminal domain of each protein binds FK506 and has peptidyl-prolyl isomerase (PPIase) activity that converts prolyl peptide bonds within target proteins from cis- to trans- proline. The C-terminal domains contain the TPR repeats involved in protein-protein interactions with the Hsp90 (4). Although FKBP52 and FKBP51 share ~75 % sequence similarity, they affect hormone binding by glucocorticoid receptor in opposing manners and have different Hsp90-binding characteristics (3). FK506 binding protein 51 kDa (FKBP51 or otherwise referred to as FKBP54) has been identified as a progestininducible gene. This protein is predominantly expressed in murine T cells but in humans, it is abundantly expressed in numerous tissues at levels many times higher than FKBP12. The FKBP51 gene is known to be induced by glucocorticoids (5).Synonyms: 51 kDa FK506-binding protein, 54 kDa progesterone receptor-associated immunophilin, AIG6, Androgen-regulated protein 6, FF1 antigen, FK506-binding protein 5, FKBP54, HSP90-binding immunophilin, Peptidyl-prolyl cis-trans isomerase FKBP5, Rotamase
-
基因ID
- 2289
-
UniProt
- Q13451
抗原
-
