tau 抗体 (pSer202, pSer519)
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Quick Overview for tau 抗体 (pSer202, pSer519) (ABIN2568469)
抗原
See all tau 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- pSer202, pSer519
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特异性
- The antibody detects endogenous levels of Tau only when phosphorylated at serine 519/202.
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纯化方法
- Antibodies were purified by affinity-chromatography using epitope-specific peptide.
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免疫原
- Tau (phospho Ser519/202) antibody was raised against a peptide sequence around phosphorylation site of Serine 519/202 (P-G-S (p)-P-G) derived from Human Tau.
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亚型
- IgG
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应用备注
- Western Blot: 1:500~1:1000
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store antibody at -20°C for up to one year.
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- tau (tau Protein)
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别名
- tau
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背景
- Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.
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分子量
- 85 kDa
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基因ID
- 4137
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NCBI登录号
- NP_058519
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UniProt
- P10636
抗原
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