DTX3L 抗体 (AA 651-740)
Quick Overview for DTX3L 抗体 (AA 651-740) (ABIN2559608)
抗原
See all DTX3L 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 651-740
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交叉反应
- 人, 小鼠, 大鼠
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预测反应
- Rabbit
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纯化方法
- Purified by Protein A.
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免疫原
- KLH conjugated synthetic peptide derived from human DTX3L
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亚型
- IgG
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anti-Deltex E3 ubiquitin ligase 3L (DTX3L) (AA 3-110) antibody
DTX3L 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 1D10 unconjugated
anti-Deltex E3 ubiquitin ligase 3L (DTX3L) (AA 3-110) antibodyDTX3L 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
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应用备注
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ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500 -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
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有效期
- 12 months
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- DTX3L (Deltex E3 ubiquitin ligase 3L (DTX3L))
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别名
- DTX3L
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背景
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Synonyms: BBAP, E3 ubiquitin-protein ligase DTX3L, B-lymphoma- and BAL-associated protein, Protein deltex-3-like, Rhysin-2, Rhysin2, DTX3L
Background: Ubiquitin ligase that mediates monoubiquitination of 'Lys-91' of histone H4 (H4K91ub1), in response to DNA damage. Protects cells exposed to DNA-damaging agents. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 'Lys-20' methylation (H4K20me). Involved in the recruitment of 53BP1/TP53BP1 to sites of DNA damage by mediating H4K91ub1 formation. In concert with PARP9, plays a role in PARP1-dependent DNA damage repair. PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites.
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基因ID
- 151636
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UniProt
- Q8TDB6
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途径
- Notch Signaling
抗原
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