Glutamate Receptor 1 抗体 (AA 1-389) (Biotin)
Quick Overview for Glutamate Receptor 1 抗体 (AA 1-389) (Biotin) (ABIN2485603)
抗原
See all Glutamate Receptor 1 (GLUR1) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
-
-
抗原表位
- AA 1-389
-
特异性
- Detects ~100 kDa. Does not cross-react with GluR2.
-
交叉反应
- 人, 小鼠, 大鼠
-
纯化方法
- Protein G Purified
-
免疫原
- Fusion protein amino acids 1-389 (extracellular N-terminus) of rat GluA1/GluR1
-
亚型
- IgG1
-
-
-
-
应用备注
-
- WB (1:1000)
- ICC/IF (1:100)
- optimal dilutions for assays should be determined by the user.
-
说明
-
1 μg/ml of ABIN2485603 was sufficient for detection of GluA1/GluR1 in 20 μg of mouse brain membrane lysate and assayed by colorimetric immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody.
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
浓度
- 1 mg/mL
-
缓冲液
- PBS pH 7.4, 50 % glycerol, 0.1 % sodium azide, Storage buffer may change when conjugated
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- 4 °C
-
储存方法
- Conjugated antibodies should be stored at 4°C
-
-
- Glutamate Receptor 1 (GLUR1)
-
别名
- GluR1
-
背景
- Glutamic acid is the major excitatory neurotransmitter in the mammalian central nervous system. Glutamate receptors are classified on the basis of their activation by different agonists (1-3). GluR1, human glutamate receptor type 1, is an integral membrane protein that is widely expressed in the human brain. The postsynaptic actions of glutamic acid are mediated by a variety of receptors that are named according to their selective agonists. GluR1 is known to bind a kainate subtype of agonist. It has been found that malfunctioning of the glutamatergic system may result in certain brain disorders and neurodegeneration (3).
-
基因ID
- 50592
-
NCBI登录号
- NP_113796
-
UniProt
- P19490
-
途径
- PI3K-Akt Signaling
抗原
-