Cyclin A1 抗体 (full length)
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北京 101111
Quick Overview for Cyclin A1 抗体 (full length) (ABIN2470210)
抗原
See all Cyclin A1 (CCNA1) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- full length
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纯化方法
- Delipidation and Defibrination
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免疫原
- Full length synthetic polypeptide corresponding to the human gene sequence.
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应用备注
- Cyclin A1 antibody can be used in ELISA, and immunohistochemistry starting at 10 μg/mL.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- 0.01 % Sodium azide
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注意事项
- As with all antibodies avoid freeze/thaw cycles.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store Cyclin A1 antibody at 4 °C or -20 °C.
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- Cyclin A1 (CCNA1)
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别名
- Cyclin A1
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背景
- The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. The cyclin encoded by this gene was shown to be expressed in testis and brain, as well as in several leukemic cell lines, and is thought to primarily function in the control of the germline meiotic cell cycle. This cyclin binds both CDK2 and CDC2 kinases, which give two distinct kinase activities, one appearing in S phase, the other in G2, and thus regulate separate functions in cell cycle. This cyclin was found to bind to important cell cycle regulators, such as Rb family proteins, transcription factor E2F-1, and the p21 family proteins. Multiple transcript variants encoding different isoforms have been found for this gene.
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基因ID
- 8900
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UniProt
- P78396
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途径
- Apoptosis, Cell Division Cycle, AMPK Signaling, Mitotic G1-G1/S Phases, DNA Replication, M Phase, Synthesis of DNA
抗原
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