SKIL 抗体 (AA 600-684)
Quick Overview for SKIL 抗体 (AA 600-684) (ABIN2470140)
抗原
See all SKIL 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 600-684
-
纯化方法
- Protein G Column
-
免疫原
- SKIL antibody was raised against amino acids 600 - 684 of SKIL (Human).
-
亚型
- IgG
-
-
anti-SKI-Like Oncogene (SKIL) (AA 307-684) antibody
SKIL 适用: 人 WB, IHC, IHC (p) 宿主: 小鼠 Monoclonal 3E2 unconjugated
anti-SKI-Like Oncogene (SKIL) (AA 359-579) antibodySKIL 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-SKI-Like Oncogene (SKIL) (AA 236-313) antibodySKIL 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1C12 unconjugated
anti-SKI-Like Oncogene (SKIL) (C-Term) antibodySKIL 适用: 人, 小鼠, 大鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-SKI-Like Oncogene (SKIL) (AA 301-400) antibodySKIL 适用: 小鼠 WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-SKI-Like Oncogene (SKIL) (C-Term) antibodySKIL 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-SKI-Like Oncogene (SKIL) (C-Term) antibodySKIL 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-SKI-Like Oncogene (SKIL) (AA 307-684) antibodySKIL 适用: 人, 小鼠, 大鼠, 犬, 猴 WB, IHC, IHC (p) 宿主: 小鼠 Monoclonal 2F6 unconjugated
anti-SKI-Like Oncogene (SKIL) (AA 542-591) antibodySKIL 适用: 人, 大鼠, Cow, 豚鼠, Pig, 猴, Bat, Hamster WB 宿主: 兔 Polyclonal unconjugated
anti-SKI-Like Oncogene (SKIL) (C-Term) antibodySKIL 适用: 人, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
-
-
应用备注
- SKIL antibody can be used in ELISA, Western Blot starting at 1:500 - 1:1000, and immunohistochemistry starting at 2.5 μg/mL.
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
缓冲液
- PBS, 0.2 % gelatin, 0.05 % sodium azide.
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
注意事项
- As with all antibodies avoid freeze/thaw cycles.
-
储存条件
- 4 °C/-20 °C
-
储存方法
- SKIL antibody can be stored short term 4 °C. For long term storage aliquot and store at -20 °C.
-
-
- SKIL (SKI-Like Oncogene (SKIL))
-
别名
- SKIL
-
背景
- Principal Names: SnoN, SNO, SKI-like, Ski-related Oncogene, SnoA, SKIL Official Gene Symbol- SKIL Gen Bank Accession Number- NP_005405 Gene ID- 6498(Human) 20482 (mouse)Gene Map Locus- 3q26 (human) SnoN, an 80 kDa protein, is a member of ski family of nuclear proto-oncogenes involved in regulation of cellular transformation and differentiation. Primarily expressed in two isoforms, SnoN is localized in cytoplasm in normal tissues and non-tumorigenic primary epithelial cells. In cancer tissues or cells, SnoN is exclusively localized in the nucleus. It plays a vital role in inhibition of cell cycle arrest induced by TGF-. Upon morphological differentiation or cell-cycle arrest, SnoN translocates into the nucleus, binds to Smad2, Smad3, and Smad4 on TGF- -responsive promoters and represses their ability to activate expression of TGF- target genes. It has also been found to mediate transcriptional repression of thyroid hormone receptor, Mad and pRb. Increased expression of SnoN has been detected in many human tumor cell lines suggesting a clinical significance.
-
基因ID
- 6498
-
UniProt
- P12757
-
途径
- Positive Regulation of Response to DNA Damage Stimulus
抗原
-
