HDAC4 抗体 (AA 194-209)
Our Local Distributor
北京 101111
Quick Overview for HDAC4 抗体 (AA 194-209) (ABIN2470109)
抗原
See all HDAC4 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 194-209
-
纯化方法
- Protein G Column
-
免疫原
- Histone Deacetylase 4 antibody was raised against amino acids 194 - 209 of Histone Deacetylase 4 (Human).
-
亚型
- IgG
-
-
-
-
应用备注
- Histone Deacetylase 4 antibody can be used in immunohistochemistry starting at 10 μg/mL.
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
缓冲液
- PBS containing 0.05 % BSA and 0.05 % sodium azide
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
注意事项
- As with all antibodies avoid freeze/thaw cycles.
-
储存条件
- 4 °C/-20 °C
-
储存方法
- Histone Deacetylase 4 antibody can be stored short term 4 °C. For long term storage aliquot and store at -20 °C.
-
-
- HDAC4 (Histone Deacetylase 4 (HDAC4))
-
别名
- Histone Deacetylase 4
-
背景
- Histone deacetylase (HDAC) and histone acetyltransferase (HAT) are enzymes that regulate transcription by selectively deacetylating or acetylating the eta-amino groups of lysines located near the amino termini of core histone proteins. Eight members of HDAC family have been identified in the past several years (2,3). These HDAC family members are divided into two classes, I and II. Class I of the HDAC family comprises four members, HDAC-1, 2, 3, and 8, each of which contains a deacetylase domain exhibiting from 45 to 93 % identity in amino acid sequence. Class II of the HDAC family comprises HDAC-4, 5, 6, and 7, the molecular weights of which are all about twofold larger than those of the class I members, and the deacetylase domains are present within the C-terminal regions, except that HDAC-6 contains two copies of the domain, one within each of the N-terminal and C-terminal regions. Human HDAC-1, 2 and 3 were expressed in various tissues, but the others (HDAC-4, 5, 6, and 7) showed tissue-specific expression patterns. These results suggested that each member of the HDAC family exhibits a different, individual substrate specificity and function in vivo.
-
基因ID
- 9759
-
UniProt
- P56524
-
途径
- Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Regulation of Carbohydrate Metabolic Process
抗原
-