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FER 抗体 (truncated)

FER 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 5D2C4-8D8C12 unconjugated
产品编号 ABIN2464050
发货至: 中国
  • 抗原 See all FER 抗体
    FER (FER Tyrosine Kinase (FER))
    抗原表位
    • 26
    • 15
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    • 7
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    truncated
    适用
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    宿主
    • 91
    • 6
    小鼠
    克隆类型
    • 91
    • 6
    单克隆
    标记
    • 37
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    This FER antibody is un-conjugated
    应用范围
    • 75
    • 35
    • 26
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    • 11
    • 6
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    Western Blotting (WB), ELISA
    免疫原
    Ni-NTA purified truncated recombinant FER-His expressed in E. Coli strain BL21 (DE3).
    克隆位点
    5D2C4-8D8C12
    亚型
    IgG1
    Top Product
    Discover our top product FER Primary Antibody
  • 应用备注
    Western Blot:1:500 - 1:2,000
    ELISA:Propose dilution 1:10,000.
    Determining optimal working dilutions by titration test.
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    Ascitic fluid containing 0.03 % sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
    储存条件
    -20 °C
    储存方法
    FER monoclonal antibody can be stored at -20 °C, stable for one year.
  • 抗原
    FER (FER Tyrosine Kinase (FER))
    别名
    FER (FER 产品)
    别名
    FerT antibody, PPP1R74 antibody, TYK3 antibody, Fer antibody, Flk antibody, Flk_retired antibody, AV082135 antibody, C330004K01Rik antibody, Fert antibody, FER tyrosine kinase antibody, fer (fms/fps related) protein kinase antibody, FER antibody, Fer antibody
    背景
    FER (fer tyrosine kinase) is a member of the FPS/FES family of nontransmembrane receptor tyrosine kinases, which shares a functional domain and is involved in signaling pathways through receptor tyrosine kinases (RTK) and cytokine receptors. The Fes /Fps family is distinct from c-Src, c-Abl and related nRTKs and was originally distinguished as a homolog to retroviral oncoproteins. In vivo, Fer kinase assembles into homotrimers via conserved coiled-coil domains. The N-terminal coiled-coil domains of Fer can autophosphorylate in trans, thereby regulating their cellular function through differential phosphorylation states. Growth factor exposure can induce tyrosine phosphorylation of Fer and recruitment of Fer to RTK complexes containing p85. It is expressed predominantly in mature hematopoietic cells of the granulocytic and monocytic lineage, and has been shown to be expressed in vascular endothelial cells. Fer is implicated in insulin signaling, cell-cell signaling, human prostatic proliferative diseases, and is involved in the regulation of G1 progression.
    基因ID
    2241
    UniProt
    P16591
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