CDK8 抗体
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北京 101111
Quick Overview for CDK8 抗体 (ABIN2463684)
抗原
See all CDK8 抗体适用
宿主
克隆类型
标记
应用范围
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纯化方法
- Antibody is purified by protein A chromatography method.
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免疫原
- Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human CDK8.
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应用备注
- CDK8 antibody can be used for detection of CDK8 by ELISA at 1:12500. CDK8 antibody can be used for detection of CDK8 by western blot at 1.25 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 100 ?L of distilled water. Final antibody concentration is 1 mg/mL.
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浓度
- 1 mg/mL
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缓冲液
- Antibody is lyophilized in PBS buffer with 2 % sucrose.
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注意事项
- As with any antibody avoid repeat freeze-thaw cycles.
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储存条件
- 4 °C/-20 °C
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储存方法
- For short periods of storage (days) store at 4 °C. For longer periods of storage, store CDK8 antibody at -20 °C.
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- CDK8 (Cyclin-Dependent Kinase 8 (CDK8))
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别名
- CDK8
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背景
- The protein encoded by CDK8 is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase and its regulatory subunit cyclin C are components of the RNA polymerase II holoenzyme complex, which phosphorylates the carboxy-terminal domain (CTD) of the largest subunit of RNA polymerase II. This kinase has also been shown to regulate transcription by targeting the CDK7/cyclin H subunits of the general transcription initiation factor IIH (TFIIH), thus providing a link between the 'Mediator-like' protein complexes and the basal transcription machinery.
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分子量
- 53 kDa
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基因ID
- 1024
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NCBI登录号
- NP_001251
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UniProt
- P49336
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途径
- Cell Division Cycle, Regulation of Lipid Metabolism by PPARalpha
抗原
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