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PRP19 抗体

This anti-PRP19 antibody is a 兔 多克隆 antibody detecting PRP19 in WB, IHC 和 ELISA. Suitable for 人, 小鼠, 大鼠, 犬 和 斑马鱼.
产品编号 ABIN2462671
发货至: 中国

Quick Overview for PRP19 抗体 (ABIN2462671)

抗原

See all PRP19 (PRPF19) 抗体
PRP19 (PRPF19) (Pre-mRNA Processing Factor 19 (PRPF19))

适用

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人, 小鼠, 大鼠, 犬, 斑马鱼

宿主

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克隆类型

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多克隆

标记

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This PRP19 antibody is un-conjugated

应用范围

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Western Blotting (WB), Immunohistochemistry (IHC), ELISA
  • 纯化方法

    Antibody is purified by protein A chromatography method.

    免疫原

    Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human PRPF19.
  • 应用备注

    PRPF19 antibody can be used for detection of PRPF19 by ELISA at 1:1562500. PRPF19 antibody can be used for detection of PRPF19 by western blot at 2.5 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

    限制

    仅限研究用
  • 状态

    Lyophilized

    溶解方式

    Add 100 ?L of distilled water. Final antibody concentration is 1 mg/mL.

    浓度

    1 mg/mL

    缓冲液

    Antibody is lyophilized in PBS buffer with 2 % sucrose.

    注意事项

    As with any antibody avoid repeat freeze-thaw cycles.

    储存条件

    4 °C/-20 °C

    储存方法

    For short periods of storage (days) store at 4 °C. For longer periods of storage, store PRPF19 antibody at -20 °C.
  • 抗原

    PRP19 (PRPF19) (Pre-mRNA Processing Factor 19 (PRPF19))

    别名

    PRPF19

    背景

    PRPF19 plays a role in DNA double-strand break (DSB) repair and pre-mRNA splicing reaction. It binds double-stranded DNA in a sequence-nonspecific manner. PRPF19 acts as a structural component of the nuclear framework. It may also serve as a support for spliceosome binding and activity. It is essential for spliceosome assembly in a oligomerization-dependent manner and might also be important for spliceosome stability. It also may have E3 ubiquitin ligase activity. The PSO4 complex is required in the DNA interstrand cross-links (ICLs) repair process. Overexpression of PRPF19 might extend the cellular life span by increasing the resistance to stress or by improving the DNA repair capacity of the cells.In S. cerevisiae, Pso4 has pleiotropic functions in DNA recombination and in error-prone nonhomologous end-joining DNA repair.

    分子量

    55 kDa

    基因ID

    27339

    NCBI登录号

    NP_055317

    UniProt

    Q9UMS4

    途径

    Ribonucleoprotein Complex Subunit Organization
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