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- 抗原 See all GAPVD1 抗体
- GAPVD1 (GTPase Activating Protein and VPS9 Domains 1 (GAPVD1))
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适用
- 人, 小鼠, 犬, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This GAPVD1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
- 纯化方法
- Antibody is purified by peptide affinity chromatography method.
- 免疫原
- Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human GAPVD1.
- Top Product
- Discover our top product GAPVD1 Primary Antibody
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anti-GTPase Activating Protein and VPS9 Domains 1 (GAPVD1) (AA 1-629) antibody
GAPVD1 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-GTPase Activating Protein and VPS9 Domains 1 (GAPVD1) (AA 182-231) antibodyGAPVD1 适用: 人, 小鼠, 犬, 大鼠, Cow, 豚鼠, 马, 兔, Bat, 小鸡, 猴, Pig WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-GTPase Activating Protein and VPS9 Domains 1 (GAPVD1) (N-Term) antibodyGAPVD1 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-GTPase Activating Protein and VPS9 Domains 1 (GAPVD1) (AA 1-260) antibodyGAPVD1 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-GTPase Activating Protein and VPS9 Domains 1 (GAPVD1) (N-Term) antibodyGAPVD1 适用: 人, 小鼠, 犬, 大鼠, Cow, 豚鼠, 马, 兔, 斑马鱼 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-GTPase Activating Protein and VPS9 Domains 1 (GAPVD1) antibodyGAPVD1 适用: 小鼠 IF 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- GAPVD1 antibody can be used for detection of GAPVD1 by ELISA at 1:312500. GAPVD1 antibody can be used for detection of GAPVD1 by western blot at 0.25 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Add 50 ?L of distilled water. Final antibody concentration is 1 mg/mL.
- 浓度
- 1 mg/mL
- 缓冲液
- Antibody is lyophilized in PBS buffer with 2 % sucrose.
- 注意事项
- As with any antibody avoid repeat freeze-thaw cycles.
- 储存条件
- 4 °C/-20 °C
- 储存方法
- For short periods of storage (days) store at 4 °C. For longer periods of storage, store GAPVD1 antibody at -20 °C.
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- 抗原
- GAPVD1 (GTPase Activating Protein and VPS9 Domains 1 (GAPVD1))
- 别名
- GAPVD1 (GAPVD1 产品)
- 别名
- zgc:92666 antibody, GAPEX5 antibody, RAP6 antibody, 2010005B09Rik antibody, 4432404J10Rik antibody, AW108497 antibody, Gapex-5 antibody, RME-6 antibody, mKIAA1521 antibody, RGD1307479 antibody, GTPase activating protein and VPS9 domains 1 antibody, GTPase activating protein and VPS9 domains 1 S homeolog antibody, LOAG_00609 antibody, GAPVD1 antibody, gapvd1 antibody, gapvd1.S antibody, Gapvd1 antibody
- 背景
- GAPVD1 acts both as a GTPase-activating protein (GAP) and a guanine nucleotide exchange factor (GEF), and participates in various processes such as endocytosis, insulin receptor internalization or LC2A4/GLUT4 trafficking. It acts as a GEF for the Ras-related protein RAB31 by exchanging bound GDP for free GTP, leading to regulate LC2A4/GLUT4 trafficking. In the absence of insulin, it maintains RAB31 in an active state and promotes a futile cycle between LC2A4/GLUT4 storage vesicles and early endosomes, retaining LC2A4/GLUT4 inside the cells. Upon insulin stimulation, it is translocated to the plasma membrane, releasing LC2A4/GLUT4 from intracellular storage vesicles. It is also involved in EGFR trafficking and degradation, possibly by promoting EGFR ubiquitination and subsequent degradation by the proteasome. It has GEF activity for Rab5 and GAP activity for Ras.
- 分子量
- 166 kDa
- 基因ID
- 26130
- NCBI登录号
- NP_056450
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