VRK1 抗体 (N-Term)
Quick Overview for VRK1 抗体 (N-Term) (ABIN2452161)
抗原
See all VRK1 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- N-Term
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特异性
- Reacts with human VRK1 protein.
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交叉反应 （详细）
- Not tested with other species.
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产品特性
- Mouse monoclonal antibody (5D1) produced in serum-free medium and purified by propriety chromatography under mild conditions (90~98 % pure). Isotype,IgG1 kappa
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过滤
- Sterile filtered
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免疫原
- Synthetic peptide corresponding to N-terminus of human VRK1,MPRVKAAQAGRQSSAKRHL-C
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亚型
- IgG2 kappa
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anti-Vaccinia Related Kinase 1 (VRK1) (AA 287-396) antibody
VRK1 适用: 人 WB, ELISA, IP, IF, RNAi 宿主: 小鼠 Monoclonal 4F9 unconjugated
anti-Vaccinia Related Kinase 1 (VRK1) (AA 257-396) antibodyVRK1 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Vaccinia Related Kinase 1 (VRK1) (AA 1-396) antibodyVRK1 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Vaccinia Related Kinase 1 (VRK1) (AA 1-396) antibodyVRK1 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Vaccinia Related Kinase 1 (VRK1) antibodyVRK1 适用: 人, 小鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Vaccinia Related Kinase 1 (VRK1) antibodyVRK1 适用: 人, 小鼠, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Vaccinia Related Kinase 1 (VRK1) antibodyVRK1 适用: 人 WB 宿主: 小鼠 Monoclonal 5C1 unconjugated
anti-Vaccinia Related Kinase 1 (VRK1) (AA 287-396) antibodyVRK1 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Vaccinia Related Kinase 1 (VRK1) (Internal Region) antibodyVRK1 适用: 人, 小鼠, 大鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Vaccinia Related Kinase 1 (VRK1) (AA 292-329), (C-Term) antibodyVRK1 适用: 人, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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1. Western blotting: 1/200~1/1,000 dilution. Use of highly sensitive chemiluminescence reagents such as Lumi-Light Plus (Roche) or ImmunoStaroR LD (Wako,Tokyo) are recommended.
2. Immunoprecipitation (assay dependent)
3. Immunofluorescence staining: 1/100 dilution
4. Immunohistochemistry (assay dependent)
5. ELISA (assay dependent) -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- PBS with 50 % Glycerol
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储存液
- Azide free
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储存条件
- -20 °C
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- VRK1 (Vaccinia Related Kinase 1 (VRK1))
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别名
- VRK1
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背景
- Function, The VRK1 gene encodes serine/threonine kinase VRK1 (Vaccinia-Related Kinase 1, 396 aa, 45.5 kDa) which is involved in Golgi disassembly during the cell cycle following phosphorylation by PLK3 during mitosis, and required to induce Golgi fragmentation. It acts by mediating phosphorylation of a downstream target protein 'Thr-18' of p53/TP53 and may thereby prevent the interaction between p53/TP53 and MDM2. It also phosphorylates casein and histone H3. Phosphorylation of the BANF1 gene product disrupts its ability to bind DNA, reduces its binding to LEM domain-containing proteins and causes its relocalization from the nucleus to the cytoplasm. Involvement in disease Defects in VRK1 are the cause of pontocerebellar hypoplasia type 1A (PCH1A), also called pontocerebellar hypoplasia with infantile spinal muscular atrophy or pontocerebellar hypoplasia with anterior horn cell disease. PCH1A is characterized by an abnormally small cerebellum and brainstem, central and peripheral motor dysfunction from birth, gliosis and anterior horn cell degeneration resembling infantile spinal muscular atrophy
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基因ID
- 7443
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UniProt
- Q99986
抗原
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