GLO1 抗体 (full length)
Quick Overview for GLO1 抗体 (full length) (ABIN2451990)
抗原
See all GLO1 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- full length
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特异性
- Specific to human, simian, and mouse glyoxalase I.
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交叉反应 (详细)
- Not tested in other species.
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产品特性
- The antibody was produced from the hybridoma cultured in serum-free medium and purified under mild conditions by propriety chromatography processes.
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纯化方法
- Purified
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过滤
- Sterile filtered
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免疫原
- Recombinant GST-fused mouse glyoxalase I (full length)
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亚型
- IgG2b kappa
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应用备注
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1. Western blotting: ~ 1,000
2. Immunocytochemistry
3. ELISA
Other applications are not tested. -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- PBS, 50 % glycerol
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储存液
- Azide free
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储存条件
- -20 °C/-80 °C
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储存方法
- -20 C (For long term storage: -70 C)
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: "Glyoxalase 1 and glutathione reductase 1 regulate anxiety in mice." in: Nature, Vol. 438, Issue 7068, pp. 662-6, (2005) (PubMed).
: "Role for glyoxalase I in Alzheimer's disease." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, Issue 20, pp. 7687-92, (2004) (PubMed).
: "Proteomic studies identified a single nucleotide polymorphism in glyoxalase I as autism susceptibility factor." in: American journal of medical genetics. Part A, Vol. 131, Issue 1, pp. 11-7, (2004) (PubMed).
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: "Glyoxalase 1 and glutathione reductase 1 regulate anxiety in mice." in: Nature, Vol. 438, Issue 7068, pp. 662-6, (2005) (PubMed).
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- GLO1 (Glyoxalase I (GLO1))
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别名
- Glyoxalase 1 (GLO1)
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背景
- Glyoxalase I (GLO1) is an enzyme that plays a role in the detoxification of methylglyoxal (MG), a side-product of glycolysis, via condensation with glutathione to produce S-lactoyl-glutathione. GLO1 is a zinc metalloenzyme whose crystal structure has been solved. The bacterial and yeast enzymes are monomeric while the mammalian one is homodimeric and its sequence is well conserved. GLO1 is found over-expressed in some tumors. GLO1 has also been suggested to be involved in anxiety diseases, autism, and Alzheimer's disease.
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UniProt
- Q9CPU0
抗原
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