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GLO1 抗体 (full length)

Cited in 3+ publications. The 大鼠 单克隆 anti-GLO1 antibody (Clone 6F10) (ABIN2451990) specifically detects GLO1 in WB, ELISA, IF 和 IC. The antibody is reactive with 人 和 小鼠 samples.
产品编号 ABIN2451990
发货至: 中国
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Quick Overview for GLO1 抗体 (full length) (ABIN2451990)

抗原

See all GLO1 抗体
GLO1 (Glyoxalase I (GLO1))

适用

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  • 45
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  • 2
  • 1
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人, 小鼠

宿主

  • 67
  • 17
  • 1
大鼠

克隆类型

  • 50
  • 34
单克隆

标记

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  • 6
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  • 2
  • 2
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This GLO1 antibody is un-conjugated

应用范围

  • 67
  • 34
  • 22
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  • 10
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  • 4
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Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunochromatography (IC)

克隆位点

6F10
  • 抗原表位

    • 15
    • 10
    • 5
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    full length

    特异性

    Specific to human, simian, and mouse glyoxalase I.

    交叉反应 (详细)

    Not tested in other species.

    产品特性

    The antibody was produced from the hybridoma cultured in serum-free medium and purified under mild conditions by propriety chromatography processes.

    纯化方法

    Purified

    过滤

    Sterile filtered

    免疫原

    Recombinant GST-fused mouse glyoxalase I (full length)

    亚型

    IgG2b kappa
  • 应用备注

    1. Western blotting: ~ 1,000
    2. Immunocytochemistry
    3. ELISA
    Other applications are not tested.

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    1 mg/mL

    缓冲液

    PBS, 50 % glycerol

    储存液

    Azide free

    储存条件

    -20 °C/-80 °C

    储存方法

    -20 C (For long term storage: -70 C)
  • Hovatta, Tennant, Helton, Marr, Singer, Redwine, Ellison, Schadt, Verma, Lockhart, Barlow: "Glyoxalase 1 and glutathione reductase 1 regulate anxiety in mice." in: Nature, Vol. 438, Issue 7068, pp. 662-6, (2005) (PubMed).

    Chen, Wollmer, Hoerndli, Münch, Kuhla, Rogaev, Tsolaki, Papassotiropoulos, Götz: "Role for glyoxalase I in Alzheimer's disease." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, Issue 20, pp. 7687-92, (2004) (PubMed).

    Junaid, Kowal, Barua, Pullarkat, Sklower Brooks, Pullarkat: "Proteomic studies identified a single nucleotide polymorphism in glyoxalase I as autism susceptibility factor." in: American journal of medical genetics. Part A, Vol. 131, Issue 1, pp. 11-7, (2004) (PubMed).

  • 抗原

    GLO1 (Glyoxalase I (GLO1))

    别名

    Glyoxalase 1 (GLO1)

    背景

    Glyoxalase I (GLO1) is an enzyme that plays a role in the detoxification of methylglyoxal (MG), a side-product of glycolysis, via condensation with glutathione to produce S-lactoyl-glutathione. GLO1 is a zinc metalloenzyme whose crystal structure has been solved. The bacterial and yeast enzymes are monomeric while the mammalian one is homodimeric and its sequence is well conserved. GLO1 is found over-expressed in some tumors. GLO1 has also been suggested to be involved in anxiety diseases, autism, and Alzheimer's disease.

    UniProt

    Q9CPU0
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