ATF6 抗体 (N-Term)
(5 references)Quick Overview for ATF6 抗体 (N-Term) (ABIN2451924)
抗原
See all ATF6 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
-
-
抗原表位
- N-Term
-
特异性
- Specific to human ATF6alpha, no cross reactivity with mouse ATF6alpha
-
产品特性
- The antibody was produced from hybridoma cultured in serum-free medium and purified under mild conditions by propriety chromatography processes.
-
纯化方法
- Purified
-
过滤
- Sterile filtered
-
免疫原
- Recombinant ATF6alpha (His-tagged amino-terminal fragment of ATF6alpha)
-
亚型
- IgG2a kappa
-
-
anti-Activating Transcription Factor 6 (ATF6) (AA 1-190) antibody
ATF6 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Activating Transcription Factor 6 (ATF6) (AA 1-377) antibodyATF6 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Activating Transcription Factor 6 (ATF6) (AA 437-449) antibodyVerified ATF6 适用: 人 WB, ELISA, IF, FACS 宿主: 山羊 Polyclonal unconjugated
anti-Activating Transcription Factor 6 (ATF6) (AA 301-400) antibodyATF6 适用: 人 WB, ELISA, IF (p), IF (cc), IHC (p), FACS, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Activating Transcription Factor 6 (ATF6) (AA 350-377) antibodyATF6 适用: 人 WB, IHC (p), FACS 宿主: 兔 Polyclonal RB22035 unconjugated
anti-Activating Transcription Factor 6 (ATF6) (AA 350-377) antibodyATF6 适用: 人 WB, IHC, ELISA, FACS 宿主: 兔 Polyclonal unconjugated
anti-Activating Transcription Factor 6 (ATF6) (AA 423-646) antibodyATF6 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Activating Transcription Factor 6 (ATF6) (AA 91-193) antibodyATF6 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 3D5 unconjugated
anti-Activating Transcription Factor 6 (ATF6) (N-Term) antibodyATF6 适用: 人, 小鼠 WB, IP 宿主: 小鼠 Monoclonal 37-1 unconjugated
anti-Activating Transcription Factor 6 (ATF6) (AA 431-530) antibodyATF6 适用: 人, 大鼠 WB, ELISA, IF (p), IF (cc), IHC (p), ICC, IHC (fro) 宿主: 兔 Polyclonal unconjugated
-
-
应用备注
-
1. Western blotting
2. Immunoprecipitation (IP)
This antibody does not work for immunofluorescence analyses. -
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
浓度
- 1 mg/mL
-
缓冲液
- PBS with 50 % Glycerol
-
储存液
- Azide free
-
储存条件
- -20 °C
-
-
-
: "Ebola Virus Activates IRE1α-Dependent XBP1u Splicing." in: Viruses, Vol. 15, Issue 1, (2023) (PubMed).
: "Selective activation of the transcription factor ATF6 mediates endoplasmic reticulum proliferation triggered by a membrane protein." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 108, Issue 19, pp. 7832-7, (2011) (PubMed).
: "Divest yourself of a preconceived idea: transcription factor ATF6 is not a soluble protein!" in: Molecular biology of the cell, Vol. 21, Issue 9, pp. 1435-8, (2010) (PubMed).
: "Transcriptional induction of mammalian ER quality control proteins is mediated by single or combined action of ATF6alpha and XBP1." in: Developmental cell, Vol. 13, Issue 3, pp. 365-76, (2007) (PubMed).
: "Transcription factor ATF cDNA clones: an extensive family of leucine zipper proteins able to selectively form DNA-binding heterodimers." in: Genes & development, Vol. 3, Issue 12B, pp. 2083-90, (1990) (PubMed).
-
: "Ebola Virus Activates IRE1α-Dependent XBP1u Splicing." in: Viruses, Vol. 15, Issue 1, (2023) (PubMed).
-
- ATF6 (Activating Transcription Factor 6 (ATF6))
-
别名
- ATF6 alpha
-
背景
- ATF6 (activating transcription factor 6) is an endoplasmic reticulum (ER) membrane-bound transcription factor activated in response to ER stress. When unfolded proteins accumulate in the ER, ATF6 is cleaved by regulated intramembrane proteolysis. The resulting amino-terminal fragment translocates to the nucleus and activates transcription by binding to ER stress-response elements present in the promoter regions of ER stress-inducible genes including those encoding ER chaperones and components of ER-associated degradation. The mammalian ATF6 family consists of two closely related homologs, ATF6alpha and ATF6beta. ATF6alpha but not ATF6beta plays a pivotal role in transcriptional control. The monoclonal antibody was characterized in the laboratory of Professor Kazutoshi Mori of Kyoto University.
-
UniProt
- P18850
-
途径
- ER-Nucleus Signaling, Unfolded Protein Response
抗原
-
