HMGCR 抗体 (full length)
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北京 101111
Quick Overview for HMGCR 抗体 (full length) (ABIN2443869)
抗原
See all HMGCR 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- full length
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原理
- HMG Co A reductase Rabbit Polyclonal Antibody
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特异性
- The antibody recognizes the HMG CoA reductase
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免疫原
- Full length protein
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anti-3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR) (AA 629-888) antibody
HMGCR 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR) (AA 638-887) antibodyHMGCR 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR) (AA 268-842) antibodyHMGCR 适用: 人 WB, IHC, ELISA, FACS, IF 宿主: 兔 Polyclonal unconjugated
anti-3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR) (pSer872) antibodyHMGCR 适用: 人, 大鼠, 小鼠 WB, ELISA, FACS, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR) (N-Term) antibodyHMGCR 适用: 人, 大鼠, 小鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR) (AA 588-887) antibodyHMGCR 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR) (AA 251-350) antibodyHMGCR 适用: 人, 大鼠, 小鼠 WB, ELISA, FACS, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR) (Internal Region) antibodyVerified HMGCR 适用: 人 ELISA, FACS, IF 宿主: 山羊 Polyclonal unconjugated
anti-3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR) antibodyHMGCR 适用: 人 WB, FACS 宿主: 兔 Monoclonal 23GB6220 unconjugated Recombinant Antibody
anti-3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR) antibodyHMGCR 适用: 人 WB, FACS 宿主: 兔 Monoclonal 24GB4895 unconjugated Recombinant Antibody
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应用备注
- WB 1:500,IF 1:50-1:100
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- If reconstituted with deionized water in 100 μL: WB 1:500, IF 1:50-1:100. Optimal dilution has to be determined by the user.
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缓冲液
- Lyophilized serum
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储存液
- Without preservative
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储存条件
- 4 °C,-20 °C,-80 °C
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储存方法
- Lyophilized antibodies can be kept at 4°C for up to 3 months and should be kept at -20°C for long-term storage (2 years). To avoid freeze-thaw cycles, reconstituted antibodies should be aliquoted before freezing for long-term (1 year) storage (-80°C) or kept at 4°C for short-term usage (2 months). For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made with the assay buffer. After the maximum long-term storage period (2 years lyophilized or 1 year reconstituted) antibodies should be tested in your assay with a standard sample to verify if you have noticed any decrease in their efficacy. To limit antibody loss or degradation, BSA (final concentration 1%) and sodium azide (final concentration 0.02%) can be added to the suggested first dilution. It is important to first verify if those preservatives are compatible with your assay.
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有效期
- 24 months
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- HMGCR (3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR))
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别名
- HMG Co A reductase
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背景
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3-hydroxy-3-methyl-glutaryl-CoA reductase, HMGCR
HMG-CoA reductase (also known as 3-hydroxy-3-methyl-glutaryl-CoA reductase or HMGCR) is a transmembrane glycoprotein involved in the control of cholesterol biosynthesis. It is the rate-limiting enzyme of sterol biosynthesis, it is a ubiquitously expressed glycoprotein that is bound to the membrane of the endoplasmic reticulum. HMG-CoA reductase is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. HMG-CoA is inhibited by statin, a class of cholesterol-lowering drugs which lower plasma cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor.
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UniProt
- P51639
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途径
- AMPK Signaling, Negative Regulation of Hormone Secretion, Regulation of Lipid Metabolism by PPARalpha
抗原
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