Caspase 6 抗体 (active)
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北京 101111
Quick Overview for Caspase 6 抗体 (active) (ABIN2443738)
抗原
See all Caspase 6 (CASP6) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- active
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原理
- Active Caspase-6 Rabbit Polyclonal Antibody
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特异性
- The antibody recognizes the human active caspase-6
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免疫原
- peptide PLDVVD
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anti-Caspase 6, Apoptosis-Related Cysteine Peptidase (CASP6) (AA 194-293) antibody
CASP6 适用: Cow WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Caspase 6, Apoptosis-Related Cysteine Peptidase (CASP6) (AA 81-179) antibodyCASP6 适用: Cow WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Caspase 6, Apoptosis-Related Cysteine Peptidase (CASP6) (AA 194-293) antibodyCASP6 适用: 人 ELISA, ICC, FACS 宿主: 小鼠 Monoclonal 3B7E10 unconjugated
anti-Caspase 6, Apoptosis-Related Cysteine Peptidase (CASP6) (AA 24-44), (N-Term) antibodyCASP6 适用: 人 WB, IHC, FACS 宿主: 兔 Polyclonal unconjugated
anti-Caspase 6, Apoptosis-Related Cysteine Peptidase (CASP6) (AA 7-27) antibodyCASP6 适用: 小鼠, 大鼠 WB, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Caspase 6, Apoptosis-Related Cysteine Peptidase (CASP6) (AA 81-179) antibodyCASP6 适用: Cow WB, IHC 宿主: 小鼠 Monoclonal C1 unconjugated
anti-Caspase 6, Apoptosis-Related Cysteine Peptidase (CASP6) antibodyKD Validated CASP6 适用: 人 WB, FACS 宿主: 兔 Monoclonal 23GB1225 unconjugated Recombinant Antibody
anti-Caspase 6, Apoptosis-Related Cysteine Peptidase (CASP6) (AA 7-27), (N-Term) antibodyCASP6 适用: 小鼠, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Caspase 6, Apoptosis-Related Cysteine Peptidase (CASP6) (AA 151-250) antibodyCASP6 适用: 人 ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Caspase 6, Apoptosis-Related Cysteine Peptidase (CASP6) (N-Term) antibodyCASP6 适用: 人 WB, IHC, ICC, IHC (p) 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB 1:5000,IHC 1:2000
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- If reconstituted with deionized water in 50 μL: WB 1:5000, IHC 1:2000. Optimal dilution has to be determined by the user.
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缓冲液
- Lyophilized serum
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储存液
- Without preservative
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储存条件
- 4 °C,-20 °C,-80 °C
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储存方法
- Lyophilized antibodies can be kept at 4°C for up to 3 months and should be kept at -20°C for long-term storage (2 years). To avoid freeze-thaw cycles, reconstituted antibodies should be aliquoted before freezing for long-term (1 year) storage (-80°C) or kept at 4°C for short-term usage (2 months). For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made with the assay buffer. After the maximum long-term storage period (2 years lyophilized or 1 year reconstituted) antibodies should be tested in your assay with a standard sample to verify if you have noticed any decrease in their efficacy. To limit antibody loss or degradation, BSA (final concentration 1%) and sodium azide (final concentration 0.02%) can be added to the suggested first dilution. It is important to first verify if those preservatives are compatible with your assay.
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有效期
- 24 months
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- Caspase 6 (CASP6) (Caspase 6, Apoptosis-Related Cysteine Peptidase (CASP6))
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别名
- Caspase6
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背景
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CASP6
Caspases are a family of cytosolic aspartate-specific cysteine proteases. Sequential activation of caspases plays a central role in the execution phase of cell apoptosis. Caspases exist as inactive proenzymes in the cytoplasm and are activated by dimerization or proteolytic cleavage. Together with caspase- 3, caspase- 6 is one of the major caspases in apoptotic cells, and functions downstream of apoptosis inhibitors Bcl-2 and Bcl-xL. Caspase- 6 has also been shown to be involved in the proteolysis of poly (ADP-ribose) polymerase (PARP) and nuclear lamin A. Recently, caspases have been considered to play roles in the neuronal cell death associated with Alzheimer's disease (AD). Caspase-dependent increased β-amyloid peptide production can occur in various cell types, specifically, caspase- 6 is thought to be responsible for increasing β-amyloid peptide in primary cultures of human neurons. Caspase- 6 has also been demonstrated to be active in neuropil threads (NPTs), neurofibrillary tangles (NFTs), and neuritic plaques (NPs) in the hippocampus and temporal cortex in sporadic AD. A role for caspase- 6 in the regulation of axonal pruning of sensory and retinocollicular axons and axonal degeneration in sensory and motor mouse neurons has also been demonstrated. As a result of its involvement in the cleavage of important synaptic and cytoskeleton proteins, in the generation of high levels of β-amyloid peptide, and for being activated very early in cognitive impairment and Alzheimer's disease (AD), activation of caspase- 6 has been considered to be involved in the development of AD.
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UniProt
- P55212
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途径
- Apoptosis, Caspase Cascade in Apoptosis
抗原
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