DAXX 抗体 (His6)
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北京 101111
Quick Overview for DAXX 抗体 (His6) (ABIN238399)
抗原
See all DAXX 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 580-740, His6
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特异性
- The antibody DAXX-03 reacts with C-terminal part of Daxx, a 110 kDa intracellular protein.
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产品特性
- Synonyms: BING2, DAP6, EAP1, Death domain-associated protein 6, Fas death domain-associatedprotein, ETS1-associated protein 1
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纯化方法
- Protein A affinity chromatography.
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免疫原
- His6-tagged protein corresponding to amino acids 580-740 of human Daxx.
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亚型
- IgG1
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应用备注
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Immunoprecipitation. Western Blotting (2 μg/mL. Immunocytochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- PBS, pH 7.4 with 15 mM sodium azide as preservative.
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C/-20 °C
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储存方法
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Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid freeze/thaw cycles.
Shelf life: One year from despatch. -
有效期
- 12 months
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- DAXX (Death-Domain Associated Protein (DAXX))
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别名
- DAXX
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背景
- Daxx is an apoptosis-modulating death-domain associated protein with functions in transcriptional regulation. Daxx functions bot in cytoplasm, where it interacts with Fas, and in nucleus (residing in PML oncogenic domains), where it is involved in SUMO-dependent regulation of transcription and subnuclear compartmentalization. Daxx senzitizes the cells to apoptosis, but on the other hand, this protein may also serve in preventing apoptosis in the early embryo. Even regarding the transcription, Daxx can serve both as a corepressor and a coactivator. During ischemic stress, Daxx translocates from the nucleus to the cytoplasm, where in regulates sodium hydrogen exchanger isoform 1 (NHE1).Synonyms: BING2, DAP6, Death domain-associated protein 6, EAP1, ETS1-associated protein 1, Fas death domain-associated protein
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基因ID
- 1616
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UniProt
- Q9UER7
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途径
- Intracellular Steroid Hormone Receptor Signaling Pathway
抗原
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