GDF15 抗体 (N-Term)
Quick Overview for GDF15 抗体 (N-Term) (ABIN238331)
抗原
See all GDF15 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
-
-
抗原表位
- AA 30-194, N-Term
-
纯化方法
- Protein G
-
免疫原
- genetic immunisation with cDNA encoding aa30-194 (N-term) of MIC-1 proprotein
-
亚型
- IgG1
-
-
-
-
应用备注
-
Flow cytometry: 1.2 µg/10^6 cells
CELISA: 1:200 - 1:400
For each application a titration should be performed to determine the optimal concentration. -
说明
-
Synonyms: GDF15
-
限制
- 仅限研究用
-
-
-
缓冲液
- PBS, pH 7.2
-
注意事项
- Avoid repeated freezing and thawing.
-
储存条件
- 4 °C
-
储存方法
- short term: 2 °C - 8 °C, long term: -20 °C
-
-
- GDF15 (Growth Differentiation Factor 15 (GDF15))
-
别名
- MIC-1
-
背景
- Macrophage inhibitory cytokine-1 (MIC-1) is a member of the transforming growth factor-ß superfamily that regulates a wide variety of physiological processes involved in tissue differentiation and maintenance. MIC-1 is synthesized as a 62-kDa intracellular protein, which, after cleavage by a furin like protease, is secreted as a 25-kDa disulphide-linked dimeric protein. Expression of MIC-1 results in inhibition of macrophage activation, regulated by the p53 pathway, in response to pro-inflammatory monokines. MIC-1 is involved in tumour pathogenesis and its measurement can be used as a clinical tool for the diagnosis of a wide range of cancers. It could be a useful marker for aggressive prostate cancer while MIC-1 is upregulated in advanced and more aggressive prostatic tumours.
-
UniProt
- Q99988
-
途径
- SARS-CoV-2 Protein Interactome
抗原
-