RAD9A 抗体 (AA 1125-1139)
Quick Overview for RAD9A 抗体 (AA 1125-1139) (ABIN225443)
抗原
See all RAD9A 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1125-1139
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特异性
- Detects Saccharomyces cerevisiae Rad9, a protein involved in the DNA damage checkpoint. In S. cerevisiae this checkpoint is mainly controlled by the PI(3) kinase-like kinase (PIKK) Mec1, which is activated in response to DNA damage. Activated Mec1 hyperphosphorylates Rad9, which in turn triggers the binding of Rad53, the ortholog of mammalian Chk2. Activated Rad53 specifically targets substrates required for cell cycle arrest, gene expression and efficient DNA repair. Mutations affecting Rad9 impair checkpoint induced cell-cycle arrest and increase genomic instability. Is pan reactive with both the phosphorylated and non-phosphorylated forms of this protein.
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纯化方法
- Purified
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免疫原
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Synthetic peptide corresponding to aa 1125-1139 of yeast Rad9 protein conjugated to Keyhole Limpet Hemocyanin (KLH).
Type of Immunogen: Synthetic peptide - KLH conjugated -
亚型
- IgG
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应用备注
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Approved: ELISA (1:2000 - 1:4000), WB (1:50 - 1:250)
Usage: Western Blot: LS-C42615 detects a band of approximately 60kD. -
说明
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Target Species of Antibody: Yeast
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- Lot specific
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缓冲液
- PBS, pH 7.2, 0.01 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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- RAD9A (RAD9 Homolog A (S. Pombe) (RAD9A))
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别名
- RAD9A / RAD9
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背景
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Name/Gene ID: RAD9A
Synonyms: RAD9A, HRAD9, RAD9, RAD9 homolog, RAD9 (S. pombe) homolog, RAD9 homolog A (S. pombe) -
基因ID
- 5883
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UniProt
- Q99638
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途径
- Positive Regulation of Response to DNA Damage Stimulus
抗原
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