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RAD9A 抗体 (AA 267-341)

RAD9A 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN7147255
发货至: 中国
  • 抗原 See all RAD9A 抗体
    RAD9A (RAD9 Homolog A (S. Pombe) (RAD9A))
    抗原表位
    • 22
    • 15
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    AA 267-341
    适用
    • 134
    • 48
    • 21
    • 5
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    宿主
    • 147
    • 8
    • 1
    克隆类型
    • 148
    • 8
    多克隆
    标记
    • 66
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    This RAD9A antibody is un-conjugated
    应用范围
    • 137
    • 85
    • 56
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    ELISA, Immunohistochemistry (IHC)
    交叉反应
    纯化方法
    >95%, Protein G purified
    免疫原
    Recombinant Human Cell cycle checkpoint control protein RAD9A protein (267-341AA)
    亚型
    IgG
    Top Product
    Discover our top product RAD9A Primary Antibody
  • 应用备注
    Recommended dilution: IHC:1:20-1:200,
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4
    储存液
    ProClin
    注意事项
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C,-80 °C
    储存方法
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 抗原
    RAD9A (RAD9 Homolog A (S. Pombe) (RAD9A))
    别名
    RAD9A (RAD9A 产品)
    别名
    RAD9 antibody, Rad9 antibody, rad9a antibody, MGC89062 antibody, XRad9 antibody, rad9 antibody, RAD9 checkpoint clamp component A antibody, RAD9 checkpoint clamp component B antibody, RAD9 checkpoint clamp component A L homeolog antibody, RAD9A antibody, Rad9a antibody, rad9a antibody, rad9b antibody, rad9a.L antibody
    背景

    Background: Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3\'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds, endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths, and DNA ligase I (LIG1) on long-patch base excision repair substrates. The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase. RAD9A possesses 3\'->5\' double stranded DNA exonuclease activity. Its phosphorylation by PRKCD may be required for the formation of the 9-1-1 complex.

    Aliases: Cell cycle checkpoint control protein antibody, Cell cycle checkpoint control protein RAD9A antibody, DNA repair exonuclease rad9 homolog A antibody, hRAD 9 antibody, hRAD9 antibody, Rad 9 antibody, RAD 9A antibody, RAD9 (S pombe) homolog antibody, RAD9 homolog A antibody, RAD9 homolog antibody, Rad9a antibody, RAD9A_HUMAN antibody

    UniProt
    Q99638
    途径
    Positive Regulation of Response to DNA Damage Stimulus
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