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ELANE 抗体

ELANE 适用: 人 IA 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN2192191
发货至: 中国
  • 抗原 See all ELANE 抗体
    ELANE (Elastase, Neutrophil Expressed (ELANE))
    适用
    • 85
    • 25
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    • 1
    宿主
    • 65
    • 19
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    • 1
    克隆类型
    • 61
    • 28
    多克隆
    标记
    • 45
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    • 2
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    This ELANE antibody is un-conjugated
    应用范围
    • 53
    • 38
    • 28
    • 16
    • 13
    • 10
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    Immunoassay (IA)
    过滤
    0.2 μm filtered
    Top Product
    Discover our top product ELANE Primary Antibody
  • 应用备注
    The antibody can be used in immuno assays. The antibody is not useful in immuno histology.
    限制
    仅限研究用
  • 缓冲液
    PBS, containing 0.02 % sodium azide and 0.1 % bovine serum albumin.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C
    储存方法
    Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one year.
    有效期
    12 months
  • Hiltermann, Lapperre, van Bree, Steerenberg, Brahim, Sont, Sterk, Hiemstra, Stolk: "Ozone-induced inflammation assessed in sputum and bronchial lavage fluid from asthmatics: a new noninvasive tool in epidemiologic studies on air pollution and asthma." in: Free radical biology & medicine, Vol. 27, Issue 11-12, pp. 1448-54, (2000) (PubMed).

    Dentener, Francot, Hiemstra, Tool, Verhoeven, Vandenabeele, Buurman: "Bactericidal/permeability-increasing protein release in whole blood ex vivo: strong induction by lipopolysaccharide and tumor necrosis factor-alpha." in: The Journal of infectious diseases, Vol. 175, Issue 1, pp. 108-17, (1997) (PubMed).

  • 抗原
    ELANE (Elastase, Neutrophil Expressed (ELANE))
    别名
    Leukocyte Elastase (ELANE 产品)
    别名
    ELA2 antibody, GE antibody, HLE antibody, HNE antibody, NE antibody, PMN-E antibody, SCN1 antibody, Ela2 antibody, F430011M15Rik antibody, ela2 antibody, ELANE antibody, elastase, neutrophil expressed antibody, proteinase 3 antibody, ELANE antibody, Elane antibody, prtn3 antibody
    背景
    Leukocyte elastase, a major serine proteinase in man, is predominantly present in the azurophilic granules of neutrophils and monocytes. Elastase has a broad range of extracellular matrix substrates including elastin, proteoglycans, collagen and fibronectin. The action of elastase is controlled by serine proteinase inhibitors. Elastase, when released during inflammation, is rapidly bound by its two main inhibitors, alpha1- PI and alpha2-macroglobuline to form elastase-inhibitor complexes. In addition mucosa secretions may contain the locally secreted elastase inhibitors elafin/SKALP and SLPI. When secreted at sites of inflammation elastase can cause severe tissue damage. An important role has been suggested for human elastase in various inflammatory disorders, including pulmonary emphysema, sepsis, arthritis, nephritis and certain skin diseases. Elastase induces the production of IL-8 in human bronchial epithelial, a proces that occurs in part through TLR4.
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