C3AR1 抗体
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北京 101111
Quick Overview for C3AR1 抗体 (ABIN2192116)
抗原
See all C3AR1 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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过滤
- 0.2 μm filtered
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应用备注
- For flow cytometry and immunohistochemistry dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50.
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限制
- 仅限研究用
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缓冲液
- PBS, containing 0.02 % sodium azide and 0.1 % bovine serum albumin.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one year.
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有效期
- 12 months
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- C3AR1 (Complement Component 3a Receptor 1 (C3AR1))
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背景
- The monoclonal antibody 74 reacts with the rat receptor for C3a. The monoclonal antibody 74 is in the literature also referred to as clone rC3aRZ1. In the course of complement activation the C3a receptor functions as the cell surface receptor for the anaphylatoxin C3a, the C-terminal 77 amino acid cleavage product of the alpha chain of C3, but not for C3a-desArg. All cellular responses to C3a are specifically mediated by interactions with the membrane bound C3a receptor, a seven transmembrane GTP-binding-protein-coupled receptor that belongs to the rhodopsin supergene family. The 54 kDa C3a receptor is widely distributed in myeloid cells, peripheral tissues and the central nervous system. Expression of C3aR has been demonstrated on neutrophils, monocytes, eosinophils, astrocytes, neurons and glial cells and is increased in inflammatory conditions. No C3aR expression was detectable on lymphocytes and on tonsillar B cells even after stimulation.
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途径
- Complement System
抗原
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