C3AR1 抗体
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北京 101111
Quick Overview for C3AR1 抗体 (ABIN2192050)
抗原
See all C3AR1 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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过滤
- 0.2 μm filtered
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应用备注
- is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50. Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one year.
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限制
- 仅限研究用
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缓冲液
- PBS, containing 0.02 % sodium azide and 0.1 % bovine serum albumin.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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- C3AR1 (Complement Component 3a Receptor 1 (C3AR1))
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背景
- The monoclonal antibody 17 reacts with the human receptor for C3a. The monoclonal antibody 17 is in the literature also referred to as clone hC3aRZ8. In the course of complement activation the C3a receptor functions as the cell surface receptor for the anaphylatoxin C3a, the C-terminal 77 amino acid cleavage product of the alpha chain of C3, but not for C3a-desArg. All cellular responses to C3a are specifically mediated by interactions with the membrane bound C3a receptor, a seven transmembrane GTP-binding-protein-coupled receptor that belongs to the rhodopsin supergene family. The 54 kDa C3a receptor is widely distributed in, myeloid cells, peripheral tissues and the central nervous system. Expression of C3aR has been demonstrated on neutrophils, monocytes, eosinophils, astrocytes, neurons and glial cells and is increased in inflammatory conditions. No C3aR expression was detectable on lymphocytes and on tonsillar B cells even after stimulation.
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途径
- Complement System
抗原
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