Galectin 3 抗体
(2 references)-
- 抗原 See all Galectin 3 (LGALS3) 抗体
- Galectin 3 (LGALS3)
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This Galectin 3 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro)), Functional Studies (Func), Immunoassay (IA)
- 过滤
- 0.2 μm filtered
- 克隆位点
- B2C10
- Top Product
- Discover our top product LGALS3 Primary Antibody
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anti-Galectin 3 (LGALS3) (AA 1-250) antibody
LGALS3 适用: 人 IF 宿主: 兔 Polyclonal unconjugated
anti-Galectin 3 (LGALS3) (AA 1-250) antibodyLGALS3 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Galectin 3 (LGALS3) antibodyLGALS3 适用: 人, 小鼠, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Galectin 3 (LGALS3) (AA 1-250) antibodyLGALS3 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Galectin 3 (LGALS3) (AA 1-250) antibodyLGALS3 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Galectin 3 (LGALS3) antibodyLGALS3 适用: 人 WB, IHC, IP 宿主: 兔 Monoclonal unconjugated
anti-Galectin 3 (LGALS3) (AA 1-250) antibodyLGALS3 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 3G8 unconjugated
anti-Galectin 3 (LGALS3) (AA 151-250) antibodyLGALS3 适用: 人, 小鼠 ELISA, IHC (p), FACS, IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Galectin 3 (LGALS3) antibodyLGALS3 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Galectin 3 (LGALS3) (AA 1-262) antibodyLGALS3 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- For immunohistology, flow cytometry and Western blotting dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50. For functional studies dilutions have to be made according to the amounts of galectin-3 to be inhibited.
- 限制
- 仅限研究用
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- 缓冲液
- PBS, containing 0.1 % bovine serum albumin.
- 储存条件
- 4 °C
- 储存方法
- Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one year.
- 有效期
- 12 months
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: "Expression of galectin-3 in normal and malignant thyroid tissue by quantitative PCR and immunohistochemistry." in: Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, Vol. 16, Issue 11, pp. 1117-23, (2003) (PubMed).
: "Human galectin-3 is a novel chemoattractant for monocytes and macrophages." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 165, Issue 4, pp. 2156-64, (2000) (PubMed).
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: "Expression of galectin-3 in normal and malignant thyroid tissue by quantitative PCR and immunohistochemistry." in: Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, Vol. 16, Issue 11, pp. 1117-23, (2003) (PubMed).
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- 抗原
- Galectin 3 (LGALS3)
- 别名
- Galectin-3 (LGALS3 产品)
- 别名
- CBP 35 antibody, Gal-3 antibody, Galectin-3 antibody, leg3 antibody, galactoside-binding antibody, galectin-3 antibody, lectin antibody, soluble antibody, CBP35 antibody, GAL3 antibody, GALBP antibody, GALIG antibody, L31 antibody, LGALS2 antibody, MAC2 antibody, MGC52947 antibody, MGC75803 antibody, LGALS3 antibody, gal-3 antibody, GBP antibody, L-34 antibody, Mac-2 antibody, gal3 antibody, galectin 3 antibody, Galectin-3 antibody, avian beta-defensin 3 antibody, lectin, galactoside-binding, soluble, 3 L homeolog antibody, lectin, galactoside-binding, soluble, 3 antibody, galectin 2 antibody, lectin, galactose binding, soluble 3 antibody, LGALS3 antibody, leg3 antibody, AvBD3 antibody, lgals3.L antibody, lgals3 antibody, LGALS2 antibody, Lgals3 antibody
- 物质类
- Chemical
- 背景
- The monoclonal antibody B2C10 reacts with galectin-3, a 30 kDa protein. Galectin-3 is a member of the galectin family. The protein is composed of three domains: a small amino-terminal domain, a carboxyl- terminal carbohydrate recognition domain (CRD) and amino-terminal domain containing repeating elements. Galectin-3 is normally distributed in epithelia of many organs and various inflammatory cells, including macrophages, as well as dendritic cells and Kupffer cells. The expression of this lectin is up- regulated during inflammation, cell proliferation, cell differentiation and through trans-activation by viral proteins. The expression is also affected by neoplastic transformation: up-regulated in certain types of lymphomas and thyroid carcinoma, while down-regulated in other types of malignancies, such as colon, breast, ovarian and uterine carcinomas. Galectin-3 has been shown to function through both intracellular and extracellular actions. Related to its intracellular functions, galectin-3 has been identified as a component of heterogeneous nuclear ribonuclear protein (hnRNP), a factor in pre-mRNA splicing, and has been found to control cell cycle and prevent T cell apoptosis. On the other hand, this protein has also been demonstrated to function as extracellular molecule in activating various types of cells, including monocytes/macrophages, mast cells, neutrophils and lymphocytes. Galectin-3 has been shown to mediate cell-cell and cell-extracellular matrix interactions. The monoclonal antibody B2C10 inhibits the binding of 125I-labeled galectin-3 to IgE coated on microtiter plates, the galecin-3's hemagglutination activity and galectin-3-induced superoxide production by human neutrophils. This inhibitory activity of B2C10 is probably the result of its disruption of the self-association process. The epitope of the monoclonal antibody B2C10 is found within the first 45 amino acids of galectin-3. The antibody B2C10 does not react with Galecin-3C and is cross reactive with mouse galectin-3.
- 途径
- RTK signaling
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